TY - JOUR
T1 - Evaluation of the Two-Needle Strategy for Reducing Reactions to DPT Vaccination
AU - Salomon, Morton E.
AU - Halperin, Richard
AU - Yee, Judy
PY - 1987/7
Y1 - 1987/7
N2 - •Using a blinded crossover design, we tested the hypothesis that changing the needle on the syringe after drawing up diphtheria-pertussis-tetanus vaccine and before injecting it reduces local complications by eliminating deposition of aluminum phosphate adjuvant in the subcutaneous track of the needle. Two hundred twenty-three children received a two-needle vaccination while 200 received a one-needle vaccination. Three hundred forty-six parents returned a questionnaire reporting their child's reaction within 48 hours of Injection. There was no significant difference in the occurrence of redness, swelling, tenderness, or limp or in parental measurements of redness and swelling between the one- and two-needle groups. Moreover, we found no differences in the frequency of systemic side effects, Including fever, vomiting, anorexia, and crying. These results do not support the practice of changing needles to reduce diphtheria-pertussis-tetanus vaccine reactions.
AB - •Using a blinded crossover design, we tested the hypothesis that changing the needle on the syringe after drawing up diphtheria-pertussis-tetanus vaccine and before injecting it reduces local complications by eliminating deposition of aluminum phosphate adjuvant in the subcutaneous track of the needle. Two hundred twenty-three children received a two-needle vaccination while 200 received a one-needle vaccination. Three hundred forty-six parents returned a questionnaire reporting their child's reaction within 48 hours of Injection. There was no significant difference in the occurrence of redness, swelling, tenderness, or limp or in parental measurements of redness and swelling between the one- and two-needle groups. Moreover, we found no differences in the frequency of systemic side effects, Including fever, vomiting, anorexia, and crying. These results do not support the practice of changing needles to reduce diphtheria-pertussis-tetanus vaccine reactions.
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U2 - 10.1001/archpedi.1987.04460070098034
DO - 10.1001/archpedi.1987.04460070098034
M3 - Article
C2 - 2954458
AN - SCOPUS:0023243220
SN - 0002-922X
VL - 141
SP - 796
EP - 798
JO - American Journal of Diseases of Children
JF - American Journal of Diseases of Children
IS - 7
ER -