Evaluation of CyberKnife Frameless Real-Time Image-Guided Stereotactic Radiosurgery for Spinal Lesions

Peter C. Gerszten, Cihat Ozhasoglu, Steven A. Burton, William Vogel, Barbara Atkins, Shalom Kalnicki, William C. Welch

Research output: Contribution to journalArticlepeer-review

50 Scopus citations


Background: This study evaluated the CyberKnife frameless image-guided radiosurgery system for the treatment of spinal lesions. Methods: This system utilizes the coupling of an orthogonal pair of X-ray cameras to a dynamically manipulated robot-mounted linear accelerator that guides the therapy beam to the intended target without the use of frame-based fixation. Cervical spine lesions are located and tracked relative to skull bony landmarks; lower spinal lesions are tracked relative to fiducial markers. 125 spinal lesions in 115 consecutive patients were treated with a single-fraction radiosurgery technique. Results: Tumor volume ranged from 0.3 to 232 ml (mean 27.8 ml). Tumor radiation dose was maintained at 12-20 Gy to the 80% isodose line (mean 14 Gy); the spinal cord or canal volume receiving greater than 8 Gy ranged from 0.0 to 1.7 ml (mean 0.2 ml). No acute radiation toxicity or new neurological deficits occurred during the follow-up period (3-24 months). Conclusions: The CyberKnife system was found to be feasible, safe and effective. The major potential benefits of radiosurgical ablation of spinal lesions are short treatment time in an outpatient setting with rapid recovery and good response.

Original languageEnglish (US)
Pages (from-to)84-89
Number of pages6
JournalStereotactic and Functional Neurosurgery
Issue number1-4
StatePublished - Dec 1 2003
Externally publishedYes


  • CyberKnife
  • Image-guided surgery
  • Robotic surgery
  • Spine tumors
  • Stereotactic radiosurgery

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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