Evaluation of association between degree of background parenchymal enhancement on MRI and breast cancer subtype

Richard Ha; Victoria Mango; Rend Al-Khalili; Eralda Mema; Lauren Friedlander; Elise Desperito; Ralph T. Wynn

doi:10.1016/j.clinimag.2018.05.008

Evaluation of association between degree of background parenchymal enhancement on MRI and breast cancer subtype

Richard Ha
, Victoria Mango
, Rend Al-Khalili
, Eralda Mema
, Lauren Friedlander
, Elise Desperito
, Ralph T. Wynn

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Purpose: Evaluate possible association between BPE and breast cancer tumor type/prognostic markers. Methods: IRB approved retrospective study from 1/2010–1/2014 identified 328 patients who had breast MRI and available clinical/pathology data. BPE was categorized according to BI-RADS. The association between BPE and breast cancer molecular subtype/prognostic factors was evaluated. Results: No significant association was present between high BPE and the following: HER2+ tumors, basal tumors, tumors with axillary nodal disease, high nuclear grade tumors, high Ki-67 index tumors or larger tumors. Conclusion: Patients with high BPE may be at increased risk for breast cancer but not necessarily for those cancer subtypes with a poor prognosis.

Original language	English (US)
Pages (from-to)	307-310
Number of pages	4
Journal	Clinical Imaging
Volume	51
DOIs	https://doi.org/10.1016/j.clinimag.2018.05.008
State	Published - Sep 1 2018
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

BPE
Breast cancer risk
Molecular subtype

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

Access to Document

10.1016/j.clinimag.2018.05.008

Cite this

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title = "Evaluation of association between degree of background parenchymal enhancement on MRI and breast cancer subtype",

abstract = "Purpose: Evaluate possible association between BPE and breast cancer tumor type/prognostic markers. Methods: IRB approved retrospective study from 1/2010–1/2014 identified 328 patients who had breast MRI and available clinical/pathology data. BPE was categorized according to BI-RADS. The association between BPE and breast cancer molecular subtype/prognostic factors was evaluated. Results: No significant association was present between high BPE and the following: HER2+ tumors, basal tumors, tumors with axillary nodal disease, high nuclear grade tumors, high Ki-67 index tumors or larger tumors. Conclusion: Patients with high BPE may be at increased risk for breast cancer but not necessarily for those cancer subtypes with a poor prognosis.",

keywords = "BPE, Breast cancer risk, Molecular subtype",

author = "Richard Ha and Victoria Mango and Rend Al-Khalili and Eralda Mema and Lauren Friedlander and Elise Desperito and Wynn, \{Ralph T.\}",

note = "Publisher Copyright: {\textcopyright} 2018",

year = "2018",

month = sep,

day = "1",

doi = "10.1016/j.clinimag.2018.05.008",

language = "English (US)",

volume = "51",

pages = "307--310",

journal = "Clinical Imaging",

issn = "0899-7071",

publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Evaluation of association between degree of background parenchymal enhancement on MRI and breast cancer subtype

AU - Ha, Richard

AU - Mango, Victoria

AU - Al-Khalili, Rend

AU - Mema, Eralda

AU - Friedlander, Lauren

AU - Desperito, Elise

AU - Wynn, Ralph T.

PY - 2018/9/1

Y1 - 2018/9/1

N2 - Purpose: Evaluate possible association between BPE and breast cancer tumor type/prognostic markers. Methods: IRB approved retrospective study from 1/2010–1/2014 identified 328 patients who had breast MRI and available clinical/pathology data. BPE was categorized according to BI-RADS. The association between BPE and breast cancer molecular subtype/prognostic factors was evaluated. Results: No significant association was present between high BPE and the following: HER2+ tumors, basal tumors, tumors with axillary nodal disease, high nuclear grade tumors, high Ki-67 index tumors or larger tumors. Conclusion: Patients with high BPE may be at increased risk for breast cancer but not necessarily for those cancer subtypes with a poor prognosis.

AB - Purpose: Evaluate possible association between BPE and breast cancer tumor type/prognostic markers. Methods: IRB approved retrospective study from 1/2010–1/2014 identified 328 patients who had breast MRI and available clinical/pathology data. BPE was categorized according to BI-RADS. The association between BPE and breast cancer molecular subtype/prognostic factors was evaluated. Results: No significant association was present between high BPE and the following: HER2+ tumors, basal tumors, tumors with axillary nodal disease, high nuclear grade tumors, high Ki-67 index tumors or larger tumors. Conclusion: Patients with high BPE may be at increased risk for breast cancer but not necessarily for those cancer subtypes with a poor prognosis.

KW - BPE

KW - Breast cancer risk

KW - Molecular subtype

UR - https://www.scopus.com/pages/publications/85048860576

UR - https://www.scopus.com/pages/publications/85048860576#tab=citedBy

U2 - 10.1016/j.clinimag.2018.05.008

DO - 10.1016/j.clinimag.2018.05.008

M3 - Article

C2 - 29945057

AN - SCOPUS:85048860576

SN - 0899-7071

VL - 51

SP - 307

EP - 310

JO - Clinical Imaging

JF - Clinical Imaging

ER -

Evaluation of association between degree of background parenchymal enhancement on MRI and breast cancer subtype

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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