Estrogen signaling through the transmembrane G protein-coupled receptor GPR30

Eric R. Prossnitz, Jeffrey B. Arterburn, Harriet O. Smith, Tudor I. Oprea, Larry A. Sklar, Helen J. Hathaway

Research output: Contribution to journalReview articlepeer-review

504 Scopus citations


Steroids play an important role in the regulation of normal physiology and the treatment of disease. Steroid receptors have classically been described as ligand-activated transcription factors mediating long-term genomic effects in hormonally regulated tissues. It is now clear that steroids also mediate rapid signaling events traditionally associated with growth factor receptors and G protein-coupled receptors. Although evidence suggests that the classical steroid receptors are capable of mediating many of these events, more recent discoveries reveal the existence of transmembrane receptors capable of responding to steroids with cellular activation. One such receptor, GPR30, is a member of the G protein-coupled receptor superfamily and mediates estrogen-dependent kinase activation as well as transcriptional responses. In this review, we provide an overview of the evidence for the cellular and physiological actions of GPR30 in estrogen-dependent processes and discuss the relationship of GPR30 with classical estrogen receptors.

Original languageEnglish (US)
Pages (from-to)165-190
Number of pages26
JournalAnnual review of physiology
StatePublished - 2008
Externally publishedYes


  • Epidermal growth factor receptor
  • Estrogen receptor
  • Steroid receptor

ASJC Scopus subject areas

  • Physiology


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