TY - JOUR
T1 - Estimation of myocardial water content using transverse relaxation time from dual spin-echo magnetic resonance imaging
AU - Boxt, Lawrence M.
AU - Hsu, Daphne
AU - Katz, Jose
AU - Detweiler, Paul
AU - Mclaughlin, Stuart
AU - Kolb, Thomas J.
AU - Spotnitz, Henry M.
PY - 1993
Y1 - 1993
N2 - Dual spin-echo magnetic resonance imaging may be used for calculation of transverse myocardial relaxation time from the signal intensity of the echoes considered. In this study, the ability of myocardial transverse relaxation time (T2) to quantitate myocardial edema of the right ventricle (RV) and left ventricle (LV) was tested. Dual spin-echo magnetic resonance images of the entire hearts were obtained and T2 of the RV and LV myocardium calculated from the signal intensities within multiple regions of interest distributed over the myocardium. Six hearts were intermittently perfused through an aortic cannula with three perfusates of decreasing osmolality. Biopsies were obtained for water content (WC) analysis both before and after imaging the hearts at baseline and post-perfusion. A seventh (control) heart was not perfused; instead dual spin-echo imaging was performed at the same time intervals as in the perfused hearts. Prior to any intervention, there was no significant difference between baseline RV (79.49 ± 2.10%) and LV (77.99 ± 2.44%, p = .2) myocardial water content; RV myocardial T2 (59.9 ± 5.8 msec) was slightly but not significantly longer than that of the LV (54.6 ± 5.7 msec, p = .1). After induction of edema, strong correlation was found between right ventricular myocardial water content measurements and right ventricular T2 (RV WC = 68.5 + 0.19 × RV T2; N = 27, R = 0.92, p < .0001, SEE = 1.56%). Similarly, strong correlation was found between left ventricular myocardial water content and T2 (LV WC = 62.1 + 0.29 × LV T2; N = 27, R = 0.92, p < .0001, SEE = 1.80%). However, slopes of these two regression lines were significantly different (p < .01). Thus, we conclude that myocardial T2 may be used to quantitate regional myocardial edema. Differences in the relationship between RV and LV myocardial water content and their effect on T2 may represent differences in the manner each tissue distributes edema fluid.
AB - Dual spin-echo magnetic resonance imaging may be used for calculation of transverse myocardial relaxation time from the signal intensity of the echoes considered. In this study, the ability of myocardial transverse relaxation time (T2) to quantitate myocardial edema of the right ventricle (RV) and left ventricle (LV) was tested. Dual spin-echo magnetic resonance images of the entire hearts were obtained and T2 of the RV and LV myocardium calculated from the signal intensities within multiple regions of interest distributed over the myocardium. Six hearts were intermittently perfused through an aortic cannula with three perfusates of decreasing osmolality. Biopsies were obtained for water content (WC) analysis both before and after imaging the hearts at baseline and post-perfusion. A seventh (control) heart was not perfused; instead dual spin-echo imaging was performed at the same time intervals as in the perfused hearts. Prior to any intervention, there was no significant difference between baseline RV (79.49 ± 2.10%) and LV (77.99 ± 2.44%, p = .2) myocardial water content; RV myocardial T2 (59.9 ± 5.8 msec) was slightly but not significantly longer than that of the LV (54.6 ± 5.7 msec, p = .1). After induction of edema, strong correlation was found between right ventricular myocardial water content measurements and right ventricular T2 (RV WC = 68.5 + 0.19 × RV T2; N = 27, R = 0.92, p < .0001, SEE = 1.56%). Similarly, strong correlation was found between left ventricular myocardial water content and T2 (LV WC = 62.1 + 0.29 × LV T2; N = 27, R = 0.92, p < .0001, SEE = 1.80%). However, slopes of these two regression lines were significantly different (p < .01). Thus, we conclude that myocardial T2 may be used to quantitate regional myocardial edema. Differences in the relationship between RV and LV myocardial water content and their effect on T2 may represent differences in the manner each tissue distributes edema fluid.
KW - MRI
KW - Myocardial edema
KW - Transverse relaxation
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U2 - 10.1016/0730-725X(93)90070-T
DO - 10.1016/0730-725X(93)90070-T
M3 - Article
C2 - 8505871
AN - SCOPUS:0027253710
SN - 0730-725X
VL - 11
SP - 375
EP - 383
JO - Magnetic Resonance Imaging
JF - Magnetic Resonance Imaging
IS - 3
ER -