ESCRT-dependent cargo sorting at multivesicular endosomes

E. B. Frankel, Anjon Audhya

Research output: Contribution to journalReview articlepeer-review

118 Scopus citations

Abstract

The endosomal sorting complex required for transport (ESCRT) machinery is composed of five multi-subunit protein complexes, which act cooperatively at specialized endosomes to facilitate the movement of specific cargoes from the limiting membrane into vesicles that bud into the endosome lumen. Over the past decade, numerous proteins, lipids, and RNAs have been shown to be incorporated into intralumenal vesicles (ILVs), but the mechanisms by which these unique cargoes are captured are only now becoming better understood. Here, we discuss the potential roles that the ESCRT machinery plays during cargo sorting at multivesicular endosomes (MVEs).

Original languageEnglish (US)
Pages (from-to)4-10
Number of pages7
JournalSeminars in Cell and Developmental Biology
Volume74
DOIs
StatePublished - Feb 2018
Externally publishedYes

Keywords

  • Cargo sorting
  • ESCRT machinery
  • Intralumenal vesicle
  • Multivesicular endosome
  • Ubiquitin

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Fingerprint

Dive into the research topics of 'ESCRT-dependent cargo sorting at multivesicular endosomes'. Together they form a unique fingerprint.

Cite this