Erythrocyte as a biological sensor

J. P.Lopes De Almeida, S. Oliveira, C. Saldanha

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations


The erythrocytes ability of sensing the local oxygen gradient through the hemoglobin conformation, along with changes in nitric oxide mobilization and vasomotor repercussions at the microcirculation, were reviewed in detail in this article. Different approachs trying to explain the erythrocyte death were additionally documented. Also, the influence of several types of molecules (vasoactive, oxidant/reductor) on the erythrocyte roles as sensor of (i) oxygen tissue needs, (ii) blood viscosity and myogenic environment, (iii) and inflammatory conditions were mentioned in order to highlight its physiologycal function and substitute the erroneous idea of the erythrocyte being simply a hemoglobin sac content.

Original languageEnglish (US)
Pages (from-to)1-20
Number of pages20
JournalClinical Hemorheology and Microcirculation
Issue number1
StatePublished - 2012
Externally publishedYes

ASJC Scopus subject areas

  • Physiology
  • Hematology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


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