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Erratum: Epigenomic State Transitions Characterize Tumor Progression in Mouse Lung Adenocarcinoma (Cancer Cell (2020) 38(2) (212–228.e13), (S153561082030310X), (10.1016/j.ccell.2020.06.006))

  • Lindsay M. LaFave
  • , Vinay K. Kartha
  • , Sai Ma
  • , Kevin Meli
  • , Isabella Del Priore
  • , Caleb Lareau
  • , Santiago Naranjo
  • , Peter M.K. Westcott
  • , Fabiana M. Duarte
  • , Venkat Sankar
  • , Zachary Chiang
  • , Alison Brack
  • , Travis Law
  • , Haley Hauck
  • , Annalisa Okimoto
  • , Aviv Regev
  • , Jason D. Buenrostro
  • , Tyler Jacks

Research output: Contribution to journalComment/debatepeer-review

Abstract

(Cancer Cell 38, 212–228; August 10, 2020) We, the authors of the paper, demonstrated that lung cancer evolution is characterized by epigenomic heterogeneity resulting from altered transcription factor activity in a mouse model. Since its publication, we have identified that several images previously described as individual tumors should more accurately be described as adjacent tumor regions, which explains the duplications of some regions within these images. Specifically, this includes “late tumors 1 and 2” in Figure 3E and the “16-week tumor” images in Figure S3G. Additionally, we discovered an accidental label swap between RUNX2 and ZEB1 in Figure S5C, as well as missing inset boxes that provide context for the zoomed images referenced in the main text. We have now provided corrected versions of Figure 3 and Figure S3, updated with contemporaneously obtained images from distinct tumors to prevent any potential confusion. Furthermore, we have rectified the labels in Figure S5 and added the necessary inset boxes to RUNX1, RUNX2, and HMGA2 stained images. The corrected figures are presented below. These clarifications and corrections do not affect the conclusions of our study. We take full responsibility for the errors in figure preparation and sincerely apologize to our readers for any confusion caused.[Figure

Original languageEnglish (US)
Pages (from-to)981-984
Number of pages4
JournalCancer Cell
Volume43
Issue number5
DOIs
StatePublished - May 12 2025

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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