Erratum: Effects of diet choice on stem cell function necessitate clarity in selection and reporting (Cell Stem Cell (2020) 27(1) (11–12), (S1934590920302812), (10.1016/j.stem.2020.06.014))

Wenge Li, Michele Houston, Karina Peregrina, Kenny Ye, Leonard H. Augenlicht

Research output: Contribution to journalComment/debatepeer-review

Abstract

(Cell Stem Cell 27, July 2, 2020) In our letter in the July 2020 issue of Cell Stem Cell, mouse gender was not stated for each diet cohort. That information is now provided in a revised Figure S1 legend. This clarifies that randomization of weanlings resulted in the chow group consisting of male mice, the purified control diet groups consisting of mixed gender mice, and the HFD group consisting of female mice. We apologize for this oversight and any resulting confusion. We compared data from gender-matched mice (males) of the control chow and control purified diet groups. For the approximately 5,000 sequences expressed in Lgr5hi cells, 20% (i.e., up to 1,000) were differentially expressed by 50% to 30-fold in the chow versus purified control groups, very similar to the results obtained from analyses of the full mixed cohorts. This suggests little impact of sex and confirms the point of our letter: that chow diet, or failure to match diets, can complicate interpretation of results.

Original languageEnglish (US)
Pages (from-to)779
Number of pages1
JournalCell Stem Cell
Volume28
Issue number4
DOIs
StatePublished - Apr 1 2021

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Cell Biology

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