TY - JOUR
T1 - Erratum
T2 - Effects of diet choice on stem cell function necessitate clarity in selection and reporting (Cell Stem Cell (2020) 27(1) (11–12), (S1934590920302812), (10.1016/j.stem.2020.06.014))
AU - Li, Wenge
AU - Houston, Michele
AU - Peregrina, Karina
AU - Ye, Kenny
AU - Augenlicht, Leonard H.
N1 - Publisher Copyright:
© 2021 Elsevier Inc.
PY - 2021/4/1
Y1 - 2021/4/1
N2 - (Cell Stem Cell 27, July 2, 2020) In our letter in the July 2020 issue of Cell Stem Cell, mouse gender was not stated for each diet cohort. That information is now provided in a revised Figure S1 legend. This clarifies that randomization of weanlings resulted in the chow group consisting of male mice, the purified control diet groups consisting of mixed gender mice, and the HFD group consisting of female mice. We apologize for this oversight and any resulting confusion. We compared data from gender-matched mice (males) of the control chow and control purified diet groups. For the approximately 5,000 sequences expressed in Lgr5hi cells, 20% (i.e., up to 1,000) were differentially expressed by 50% to 30-fold in the chow versus purified control groups, very similar to the results obtained from analyses of the full mixed cohorts. This suggests little impact of sex and confirms the point of our letter: that chow diet, or failure to match diets, can complicate interpretation of results.
AB - (Cell Stem Cell 27, July 2, 2020) In our letter in the July 2020 issue of Cell Stem Cell, mouse gender was not stated for each diet cohort. That information is now provided in a revised Figure S1 legend. This clarifies that randomization of weanlings resulted in the chow group consisting of male mice, the purified control diet groups consisting of mixed gender mice, and the HFD group consisting of female mice. We apologize for this oversight and any resulting confusion. We compared data from gender-matched mice (males) of the control chow and control purified diet groups. For the approximately 5,000 sequences expressed in Lgr5hi cells, 20% (i.e., up to 1,000) were differentially expressed by 50% to 30-fold in the chow versus purified control groups, very similar to the results obtained from analyses of the full mixed cohorts. This suggests little impact of sex and confirms the point of our letter: that chow diet, or failure to match diets, can complicate interpretation of results.
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U2 - 10.1016/j.stem.2021.03.003
DO - 10.1016/j.stem.2021.03.003
M3 - Comment/debate
C2 - 33798423
AN - SCOPUS:85103392480
SN - 1934-5909
VL - 28
SP - 779
JO - Cell Stem Cell
JF - Cell Stem Cell
IS - 4
ER -