TY - JOUR
T1 - Epileptogenesis in neonatal brain
AU - Katsarou, Anna Maria
AU - Galanopoulou, Aristea S.
AU - Moshé, Solomon L.
N1 - Funding Information:
Aristea S. Galanopoulou acknowledges grant support by NINDS RO1 NS091170 , U54 NS100064 , the US Department of Defense (W81XWH-13-1-0180), the CURE Infantile Spasms Initiative and research funding from the Heffer Family and the Segal Family Foundations and the Abbe Goldstein/Joshua Lurie and Laurie Marsh/Dan Levitz families. She is co-Editor in Chief of Epilepsia Open and has received royalties for publications from Elsevier.
Funding Information:
Solomon L. Moshé is the Charles Frost Chair in Neurosurgery and Neurology and partially funded by grants from NIH U54 NS100064 and NS43209 , U.S. Department of Defense ( W81XWH-13-1-0180 ), CURE Infantile Spasms Initiative and the Heffer Family and the Segal Family Foundations and the Abbe Goldstein/Joshua Lurie and Laurie Marsh/Dan Levitz families. He receives from Elsevier an annual compensation for his work as Associate Editor in Neurobiology of Disease and royalties from two books he co-edited. He received a consultant fee from UCB as a DSMB member.
Publisher Copyright:
© 2018 Elsevier Ltd
PY - 2018/6
Y1 - 2018/6
N2 - Epilepsy is a chronic neurological disorder affecting 65 million people worldwide. The etiologies of seizures can often be identified as genetic, metabolic, structural, immunologic or infectious, but in many cases the cause is unknown with the current diagnostic tools. Epileptogenesis is a process during which genetic or other acquired etiologies/insults lead to functional, structural, or network reorganization changes in the brain that may lead to the development of, or progression of, spontaneous seizures. During development, there are continuous changes in the structure, function, and network operation that also show sex specificity, which may alter the mechanisms underlying the generation of seizures (ictogenesis) and epileptogenesis. Understanding the mechanisms of early life epileptogenesis will enable the development of rationally designed age- and sex-appropriate therapies that would improve the overall quality of patients' lives. Here, we discuss some of these processes that may affect seizure generation and epileptogenesis in the neonatal brain.
AB - Epilepsy is a chronic neurological disorder affecting 65 million people worldwide. The etiologies of seizures can often be identified as genetic, metabolic, structural, immunologic or infectious, but in many cases the cause is unknown with the current diagnostic tools. Epileptogenesis is a process during which genetic or other acquired etiologies/insults lead to functional, structural, or network reorganization changes in the brain that may lead to the development of, or progression of, spontaneous seizures. During development, there are continuous changes in the structure, function, and network operation that also show sex specificity, which may alter the mechanisms underlying the generation of seizures (ictogenesis) and epileptogenesis. Understanding the mechanisms of early life epileptogenesis will enable the development of rationally designed age- and sex-appropriate therapies that would improve the overall quality of patients' lives. Here, we discuss some of these processes that may affect seizure generation and epileptogenesis in the neonatal brain.
KW - Epilepsy
KW - Genetic
KW - Kindling
KW - Rodent
KW - Seizure
KW - Status epilepticus
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U2 - 10.1016/j.siny.2017.12.004
DO - 10.1016/j.siny.2017.12.004
M3 - Review article
C2 - 29467100
AN - SCOPUS:85042152306
SN - 1744-165X
VL - 23
SP - 159
EP - 167
JO - Seminars in Fetal and Neonatal Medicine
JF - Seminars in Fetal and Neonatal Medicine
IS - 3
ER -