Epileptogenesis and rational therapeutic strategies

H. Stefan, F. H. Lopes Da Silva, W. Löscher, D. Schmidt, E. Perucca, M. J. Brodie, P. A.J.M. Boon, W. H. Theodore, S. L. Moshé

Research output: Contribution to journalReview articlepeer-review

43 Scopus citations


The understanding of neurobiological mechanisms of epileptogenesis is essential for rational approaches for a possible disease modification as well as treatment of underlying causes of the epilepsies. More effort is necessary to translate results from basic investigations into new approaches for clinical research and to better understand a relationship with findings from clinical studies. The following report is a condensed synapsis in which molecular mechanisms of epileptogenesis, pharmacological modulation of epileptogenesis, evidence based therapy, refractoriness and prediction of outcome is provided in order to stimulate further collaborative international research.

Original languageEnglish (US)
Pages (from-to)139-155
Number of pages17
JournalActa Neurologica Scandinavica
Issue number3
StatePublished - Mar 2006


  • Epileptogenesis
  • Evidence
  • Molecular biology
  • Neurobiological mechanisms
  • Rational treatment

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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