TY - JOUR
T1 - Epilepsy therapy development
T2 - Technical and methodologic issues in studies with animal models
AU - Galanopoulou, Aristea S.
AU - Kokaia, Merab
AU - Loeb, Jeffrey A.
AU - Nehlig, Astrid
AU - Pitkänen, Asla
AU - Rogawski, Michael A.
AU - Staley, Kevin J.
AU - Whittemore, Vicky H.
AU - Dudek, F. Edward
PY - 2013/8
Y1 - 2013/8
N2 - The search for new treatments for seizures, epilepsies, and their comorbidities faces considerable challenges. This is due in part to gaps in our understanding of the etiology and pathophysiology of most forms of epilepsy. An additional challenge is the difficulty in predicting the efficacy, tolerability, and impact of potential new treatments on epilepsies and comorbidities in humans, using the available resources. Herein we provide a summary of the discussions and proposals of the Working Group 2 as presented in the Joint American Epilepsy Society and International League Against Epilepsy Translational Workshop in London (September 2012). We propose methodologic and reporting practices that will enhance the uniformity, reliability, and reporting of early stage preclinical studies with animal seizure and epilepsy models that aim to develop and evaluate new therapies for seizures or epilepsies, using multidisciplinary approaches. The topics considered include the following: (1) implementation of better study design and reporting practices; (2) incorporation Wiley Periodicals, Inc.
AB - The search for new treatments for seizures, epilepsies, and their comorbidities faces considerable challenges. This is due in part to gaps in our understanding of the etiology and pathophysiology of most forms of epilepsy. An additional challenge is the difficulty in predicting the efficacy, tolerability, and impact of potential new treatments on epilepsies and comorbidities in humans, using the available resources. Herein we provide a summary of the discussions and proposals of the Working Group 2 as presented in the Joint American Epilepsy Society and International League Against Epilepsy Translational Workshop in London (September 2012). We propose methodologic and reporting practices that will enhance the uniformity, reliability, and reporting of early stage preclinical studies with animal seizure and epilepsy models that aim to develop and evaluate new therapies for seizures or epilepsies, using multidisciplinary approaches. The topics considered include the following: (1) implementation of better study design and reporting practices; (2) incorporation Wiley Periodicals, Inc.
KW - Infrastructure.
KW - Nonpharmacological treatment
KW - Pharmacokinetics
KW - Regulatory requirements
KW - Tolerability
KW - Video-electroencephalography
UR - http://www.scopus.com/inward/record.url?scp=84891679696&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84891679696&partnerID=8YFLogxK
U2 - 10.1111/epi.12295
DO - 10.1111/epi.12295
M3 - Article
C2 - 23909850
AN - SCOPUS:84891679696
SN - 0013-9580
VL - 54
SP - 13
EP - 23
JO - Epilepsia
JF - Epilepsia
IS - SUPPL.4
ER -