TY - JOUR
T1 - Epigenetic targets of HDAC inhibition in neurodegenerative and psychiatric disorders
AU - Abel, Ted
AU - Zukin, R. Suzanne
N1 - Funding Information:
This work was supported by NIH grant NS46742 to RSZ, NIH grant MH60244 to TA, and a generous grant from the F.M. Kirby Program in Neural Repair and Neuroprotection to RSZ.
PY - 2008/2
Y1 - 2008/2
N2 - Epigenetic chromatin remodeling and modifications of DNA represent central mechanisms for regulation of gene expression during brain development and in memory formation. Emerging evidence implicates epigenetic modifications in disorders of synaptic plasticity and cognition. This review focuses on recent findings that HDAC inhibitors can ameliorate deficits in synaptic plasticity, cognition, and stress-related behaviors in a wide range of neurologic and psychiatric disorders including Huntington's disease, Parkinson's disease, anxiety and mood disorders, Rubinstein-Taybi syndrome, and Rett syndrome. These agents may prove useful in the clinic for the treatment of the cognitive impairments that are central elements of many neurodevelopmental, neurological, and psychiatric disorders.
AB - Epigenetic chromatin remodeling and modifications of DNA represent central mechanisms for regulation of gene expression during brain development and in memory formation. Emerging evidence implicates epigenetic modifications in disorders of synaptic plasticity and cognition. This review focuses on recent findings that HDAC inhibitors can ameliorate deficits in synaptic plasticity, cognition, and stress-related behaviors in a wide range of neurologic and psychiatric disorders including Huntington's disease, Parkinson's disease, anxiety and mood disorders, Rubinstein-Taybi syndrome, and Rett syndrome. These agents may prove useful in the clinic for the treatment of the cognitive impairments that are central elements of many neurodevelopmental, neurological, and psychiatric disorders.
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U2 - 10.1016/j.coph.2007.12.002
DO - 10.1016/j.coph.2007.12.002
M3 - Review article
C2 - 18206423
AN - SCOPUS:38649124003
SN - 1471-4892
VL - 8
SP - 57
EP - 64
JO - Current Opinion in Pharmacology
JF - Current Opinion in Pharmacology
IS - 1
ER -