Epigenetic mechanisms governing the process of neurodegeneration

Irfan A. Qureshi, Mark F. Mehler

Research output: Contribution to journalReview articlepeer-review

30 Scopus citations


Studies elucidating how and why neurodegeneration unfolds suggest that a complex interplay between genetic and environmental factors is responsible for disease pathogenesis. Recent breakthroughs in the field of epigenetics promise to advance our understanding of these mechanisms and to promote the development of useful and effective pre-clinical risk stratification strategies, molecular diagnostic and prognostic methods, and disease-modifying treatments.

Original languageEnglish (US)
Pages (from-to)875-882
Number of pages8
JournalMolecular aspects of medicine
Issue number4
StatePublished - Jul 2013


  • Chromatin
  • Epigenetic
  • Histone deacetylase
  • Histone modification
  • Neurodegenerative disease
  • Non-coding RNA

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry


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