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Environmental hydrocarbons produce degeneration in cat hypothalamus and optic tract

  • Herbert H. Schaumburg
  • , Peter S. Spencer

Research output: Contribution to journalArticlepeer-review

Abstract

2,5-Hexanedione, the principal neurotoxic metabolite of the industrial solvents n-hexane and methyl n-butyl ketone causes axonal degeneration in the mammillary body and visual nuclei of cats. Prolonged, low-level exposure to hydrocarbons in the environment may cause premature deterioration in areas of the human brain vital for perception and behavior.

Original languageEnglish (US)
Pages (from-to)199-200
Number of pages2
JournalScience
Volume199
Issue number4325
DOIs
StatePublished - 1978
Externally publishedYes

ASJC Scopus subject areas

  • General

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