Enhanced Production of Functional Proteins from Defective Genes

Biao Xi, Fangxia Guan, David S. Lawrence

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Nonsense mutations are associated with a host of genetic disorders. The protein products encoded by genes containing these mutations are either truncated or completely missing. Recently, members of the aminoglycoside family of antibiotics have been found to induce the ribosome to read past these inappropriately inserted stop codons, albeit at extremely modest efficiencies. We report herein a strategy that enhances the production of functional proteins from the corresponding mutated genes.

Original languageEnglish (US)
Pages (from-to)5660-5661
Number of pages2
JournalJournal of the American Chemical Society
Issue number18
StatePublished - May 12 2004

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry
  • Biochemistry
  • Colloid and Surface Chemistry


Dive into the research topics of 'Enhanced Production of Functional Proteins from Defective Genes'. Together they form a unique fingerprint.

Cite this