Endogenous estradiol is associated with verbal memory in nondemented older men

Molly E. Zimmerman, Richard B. Lipton, Nanette Santoro, Daniel S. McConnell, Carol A. Derby, Mindy J. Katz, Khosrow Baigi, Rachel Saunders-Pullman

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


This study examined the relationship between endogenous hormones and cognitive function in nondemented, ethnically-diverse community-dwelling older men enrolled in the Einstein Aging Study (EAS). All eligible participants (185 men, mean age = 81. years) received neuropsychological assessment (Free and Cued Selective Reminding Test (FCSRT), Logical Memory (LM), Trail Making Test B (TMTB), block design (BD)) and provided blood samples for hormonal assays (total estradiol, total testosterone, calculated free testosterone index). Linear regression analysis adjusted for age, education, body mass index, and cardiovascular comorbidities indicated that men with high levels of total estradiol demonstrated better FCSRT verbal memory performance (β=. 0.17, p< 0.02) compared to men with lower levels of total estradiol. The results remained unchanged when the model was further adjusted for ethnicity. We did not detect an association between testosterone and cognitive performance. These findings indicate that high levels of total estradiol in older men are associated with better performance on a cue-based, controlled learning test of verbal memory that is a sensitive predictor of dementia.

Original languageEnglish (US)
Pages (from-to)158-165
Number of pages8
JournalBrain and Cognition
Issue number1
StatePublished - Jun 2011


  • Aging
  • Cognition
  • Estradiol
  • Hormones
  • Memory
  • Men
  • Older adults
  • Testosterone

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Experimental and Cognitive Psychology
  • Developmental and Educational Psychology
  • Arts and Humanities (miscellaneous)
  • Cognitive Neuroscience


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