Endocrine late effects in childhood cancer survivors

Wassim Chemaitilly, Laurie E. Cohen

Research output: Chapter in Book/Report/Conference proceedingChapter


Endocrine complications frequently occur as late effects of cancer treatments and have been reported to affect as many as 50% of childhood cancer survivors (CCS). CCS are also vulnerable to life-threatening chronic health conditions, such as cardiovascular disease, with known repercussions on quality of life and longevity. Radiotherapy and alkylating chemotherapy agents represent the highest treatment-related risk factors for endocrine late effects. The most frequently observed are: hypothalamic/pituitary dysfunction, primary thyroid disease, primary gonadal insufficiency, bone mineral density deficit, obesity, and diabetes mellitus. Implementing a systematic approach where CCS are periodically evaluated based on their cancer and treatment histories may allow more rapid diagnosis and treatment. This may prevent untreated endocrinopathies from further contributing to the morbidity and mortality risk of individuals within this vulnerable population.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Endocrine Diseases
Number of pages19
ISBN (Electronic)9780128122006
ISBN (Print)9780128121993
StatePublished - Jan 1 2018
Externally publishedYes


  • Alkylating agent complications
  • Chemotherapy complications
  • Chemotherapy late effects
  • Childhood cancer
  • Childhood cancer survivor
  • Cranial radiotherapy complications
  • Endocrine complications
  • Endocrine late effects
  • Hematopoietic stem cell transplantation complications
  • Radiotherapy complications
  • Radiotherapy late effects
  • Total body irradiation complications

ASJC Scopus subject areas

  • Medicine(all)


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