Electrophysiologic Properties of Nitroprusside in Man

Lawrence Gould; C. V. Ramana Reddy; S. G. Kim; K. C. Oh

doi:10.1177/000331977903001208

Electrophysiologic Properties of Nitroprusside in Man

Lawrence Gould, C. V. Ramana Reddy, S. G. Kim, K. C. Oh

Research output: Contribution to journal › Article › peer-review

Abstract

The effects of nitroprusside on His bundle electrograms, when given intra venously for 10 minutes, were studied in 14 patients with heart disease. Record ings were made at varied heart rates using atrial and ventricular pacing. Nitro prusside significantly reduced the AH interval, but it had no effect on the HV interval. Functional and effective refractory periods were measured by the ex trastimulus technique. The functional refractory period of the AV node as well as the effective refractory period of the ventriculoatrial conduction system sig nificantly decreased after nitroprusside infusion. This improvement in con duction can probably be explained by the systemic hypotension produced by nitroprusside, which reflexly will increase sympathetic drive to the heart and decrease vagal tone.

Original language	English (US)
Pages (from-to)	841-849
Number of pages	9
Journal	Angiology
Volume	30
Issue number	12
DOIs	https://doi.org/10.1177/000331977903001208
State	Published - Dec 1979
Externally published	Yes

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1177/000331977903001208

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abstract = "The effects of nitroprusside on His bundle electrograms, when given intra venously for 10 minutes, were studied in 14 patients with heart disease. Record ings were made at varied heart rates using atrial and ventricular pacing. Nitro prusside significantly reduced the AH interval, but it had no effect on the HV interval. Functional and effective refractory periods were measured by the ex trastimulus technique. The functional refractory period of the AV node as well as the effective refractory period of the ventriculoatrial conduction system sig nificantly decreased after nitroprusside infusion. This improvement in con duction can probably be explained by the systemic hypotension produced by nitroprusside, which reflexly will increase sympathetic drive to the heart and decrease vagal tone.",

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AB - The effects of nitroprusside on His bundle electrograms, when given intra venously for 10 minutes, were studied in 14 patients with heart disease. Record ings were made at varied heart rates using atrial and ventricular pacing. Nitro prusside significantly reduced the AH interval, but it had no effect on the HV interval. Functional and effective refractory periods were measured by the ex trastimulus technique. The functional refractory period of the AV node as well as the effective refractory period of the ventriculoatrial conduction system sig nificantly decreased after nitroprusside infusion. This improvement in con duction can probably be explained by the systemic hypotension produced by nitroprusside, which reflexly will increase sympathetic drive to the heart and decrease vagal tone.

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Electrophysiologic Properties of Nitroprusside in Man

Abstract

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