TY - JOUR
T1 - Electrical Coupling and Neuronal Synchronization in the Mammalian Brain
AU - Bennett, Michael V.L.
AU - Zukin, R. Suzanne
N1 - Funding Information:
This work was supported by NIH grants NS045287 (to M.V.L.B.) and NS 20752 (to R.S.Z.) and by the F.M. Kirby Foundation. We are indebted to Drs. F.F. Bukauskas and V.K. Verselis for Figure 1A .
PY - 2004/2/19
Y1 - 2004/2/19
N2 - Certain neurons in the mammalian brain have long been known to be joined by gap junctions, which are the most common type of electrical synapse. More recently, cloning of neuron-specific connexins, increased capability of visualizing cells within brain tissue, labeling of cell types by transgenic methods, and generation of connexin knockouts have spurred a rapid increase in our knowledge of the role of gap junctions in neural activity. This article reviews the many subtleties of transmission mediated by gap junctions and the mechanisms whereby these junctions contribute to synchronous firing.
AB - Certain neurons in the mammalian brain have long been known to be joined by gap junctions, which are the most common type of electrical synapse. More recently, cloning of neuron-specific connexins, increased capability of visualizing cells within brain tissue, labeling of cell types by transgenic methods, and generation of connexin knockouts have spurred a rapid increase in our knowledge of the role of gap junctions in neural activity. This article reviews the many subtleties of transmission mediated by gap junctions and the mechanisms whereby these junctions contribute to synchronous firing.
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U2 - 10.1016/S0896-6273(04)00043-1
DO - 10.1016/S0896-6273(04)00043-1
M3 - Review article
C2 - 14980200
AN - SCOPUS:1342291195
SN - 0896-6273
VL - 41
SP - 495
EP - 511
JO - Neuron
JF - Neuron
IS - 4
ER -