Efficacy of levodropropizine in pediatric cough

Francesco De Blasio, Peter V. Dicpinigaitis, Gianluca De Danieli, Luigi Lanata, Alessando Zanasi

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations


Cough in children is among the most common problems managed by pediatricians, and occurs more frequently in preschool than in older children. Most acute episodes of cough are due to viral upper respiratory tract infections. The morbidity associated with acute cough in a child extends also to parents, teachers, and other family members and caregivers. Unfortunately, therapeutic options for acute cough in children are severely limited due to the absence of drugs shown to be effective antitussives with an acceptable safety profile. Agents used in the management of adult cough, such as narcotics (codeine, hydrocodone), the non-narcotic opioid dextromethorphan, first-generation, potentially sedating antihistamines, and decongestants such as pseudoephedrine, have all been deemed inadequate for treatment of acute pediatric cough on a risk/benefit basis. A growing body of evidence suggests that the peripherally acting antitussive, levodropropizine, may be an attractive alternative for the treatment of bothersome acute cough in children.

Original languageEnglish (US)
Pages (from-to)337-342
Number of pages6
JournalPulmonary Pharmacology and Therapeutics
Issue number5
StatePublished - Oct 2012


  • Antitussives
  • Children
  • Levodropropizine
  • Pediatric

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Biochemistry, medical
  • Pharmacology (medical)


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