Effects on thrombin generation of the platelet glycoprotein IIb/IIIa inhibitors abciximab versus tirofiban during coronary intervention

John A. Ambrose; Ramy Doss; Jean Pierre M. Geagea; Marian C. Hawkey; Srinivas Duvuri; Kenneth Giedd; Alvaro Dominguez; John Coppola; Tien H. Nguyen; Venugopal Palla; Rajat S. Barua; Dhanonjoy C. Saha

doi:10.1016/S0002-9149(01)01506-5

Effects on thrombin generation of the platelet glycoprotein IIb/IIIa inhibitors abciximab versus tirofiban during coronary intervention

John A. Ambrose, Ramy Doss, Jean Pierre M. Geagea, Marian C. Hawkey, Srinivas Duvuri, Kenneth Giedd, Alvaro Dominguez, John Coppola, Tien H. Nguyen, Venugopal Palla, Rajat S. Barua, Dhanonjoy C. Saha

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The antithrombin generating effects of tirofiban were compared with abciximab in patients who underwent intervention and received intravenous heparin based on their weight. A standardized protocol serially measured the ACT, F1.2, and platelet receptor occupancy. Both GP IIb/IIIa agents had similar effects on reducing thrombin generation, and there were no significant differences between the groups at any measurement interval.

Original language	English (US)
Pages (from-to)	1231-1233
Number of pages	3
Journal	American Journal of Cardiology
Volume	87
Issue number	10
DOIs	https://doi.org/10.1016/S0002-9149(01)01506-5
State	Published - May 15 2001
Externally published	Yes

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/S0002-9149(01)01506-5

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Ambrose, J. A., Doss, R., Geagea, J. P. M., Hawkey, M. C., Duvuri, S., Giedd, K., Dominguez, A., Coppola, J., Nguyen, T. H., Palla, V., Barua, R. S., & Saha, D. C. (2001). Effects on thrombin generation of the platelet glycoprotein IIb/IIIa inhibitors abciximab versus tirofiban during coronary intervention. American Journal of Cardiology, 87(10), 1231-1233. https://doi.org/10.1016/S0002-9149(01)01506-5

Ambrose, JA, Doss, R, Geagea, JPM, Hawkey, MC, Duvuri, S, Giedd, K, Dominguez, A, Coppola, J, Nguyen, TH, Palla, V, Barua, RS & Saha, DC 2001, 'Effects on thrombin generation of the platelet glycoprotein IIb/IIIa inhibitors abciximab versus tirofiban during coronary intervention', American Journal of Cardiology, vol. 87, no. 10, pp. 1231-1233. https://doi.org/10.1016/S0002-9149(01)01506-5

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abstract = "The antithrombin generating effects of tirofiban were compared with abciximab in patients who underwent intervention and received intravenous heparin based on their weight. A standardized protocol serially measured the ACT, F1.2, and platelet receptor occupancy. Both GP IIb/IIIa agents had similar effects on reducing thrombin generation, and there were no significant differences between the groups at any measurement interval.",

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doi = "10.1016/S0002-9149(01)01506-5",

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T1 - Effects on thrombin generation of the platelet glycoprotein IIb/IIIa inhibitors abciximab versus tirofiban during coronary intervention

AU - Ambrose, John A.

AU - Doss, Ramy

AU - Geagea, Jean Pierre M.

AU - Hawkey, Marian C.

AU - Duvuri, Srinivas

AU - Giedd, Kenneth

AU - Dominguez, Alvaro

AU - Coppola, John

AU - Nguyen, Tien H.

AU - Palla, Venugopal

AU - Barua, Rajat S.

AU - Saha, Dhanonjoy C.

PY - 2001/5/15

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N2 - The antithrombin generating effects of tirofiban were compared with abciximab in patients who underwent intervention and received intravenous heparin based on their weight. A standardized protocol serially measured the ACT, F1.2, and platelet receptor occupancy. Both GP IIb/IIIa agents had similar effects on reducing thrombin generation, and there were no significant differences between the groups at any measurement interval.

AB - The antithrombin generating effects of tirofiban were compared with abciximab in patients who underwent intervention and received intravenous heparin based on their weight. A standardized protocol serially measured the ACT, F1.2, and platelet receptor occupancy. Both GP IIb/IIIa agents had similar effects on reducing thrombin generation, and there were no significant differences between the groups at any measurement interval.

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Effects on thrombin generation of the platelet glycoprotein IIb/IIIa inhibitors abciximab versus tirofiban during coronary intervention

Abstract

ASJC Scopus subject areas

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