TY - JOUR
T1 - Effects of nonsurgical periodontal treatment on glycated haemoglobin on type 2 diabetes patients (PARODIA 1 study)
T2 - A randomized controlled trial in a sub-Saharan Africa population
AU - Tsobgny-Tsague, Nadia Flore
AU - Lontchi-Yimagou, Eric
AU - Nana, Arnel Redon Nana
AU - Tankeu, Aurel T.
AU - Katte, Jean Claude
AU - Dehayem, Mesmin Y.
AU - Bengondo, Charles Messanga
AU - Sobngwi, Eugene
N1 - Publisher Copyright:
© 2018 The Author(s).
PY - 2018/2/26
Y1 - 2018/2/26
N2 - Background: There is a burglar association between diabetes and periodontitis. Many studies has shown that periodontitis treatment can help improving glycemic control in diabetes patients but little evidence of non-surgical treatment benefit is available in sub Saharan african diabetes patients. We aimed to assess the effects of non-surgical periodontal treatment (NSPT) of chronic periodontitis on glycaemic control in poorly controlled type 2 diabetes patients (T2D) in a sub-Saharan Africa urban setting. Methods: A total of 34 poorly controlled T2D patients with chronic periodontitis aged 51.4±8.8years (mean±SD), with known duration of diabetes of 55.5±42.6months, and HbA1c of 9.3±1.3% were randomly assigned to two groups. The treatment group (Group 1, n=17) received immediate ultrasonic scaling, scaling and root planning along with subgingival 10% povidone iodine irrigation, whereas the control group (Group 2, n=17) was assigned to receive delayed periodontal treatment 3months later. Pharmacological treatment was unchanged and all participants received the same standardized education session on diabetes management and dental hygiene. The primary outcome was the 3-month change in HbA1c from baseline. Plaque index (PI), gingival bleeding index (GBI), pocket depth (PD), clinical attachment loss (CAL) were also assessed prior to, at 6 and 12weeks after enrolment. Results: Two subjects in each group were excluded from the study. Data were analyzed on thirty patients (15 per group). Non-surgical periodontal treatment with education for better dental hygiene (group 1) significantly improved all periodontal parameters whereas education only (group 2) improved only the plaque index among all periodontal parameters. Immediate non-surgical periodontal treatment induced a reduction of HbA1c levels by 3.0±2.4 points from 9.7±1.6% at baseline to 6.7±2.0% 3months after NSPT, (p 0.001) but the change was not significant in group 2, from mean 8.9±0.9% at baseline vs 8.1±2.6% after 3months (p=0.24). Conclusion: Non-surgical periodontal treatment markedly improved glycaemic control with an attributable reduction of 2.2 points of HbA1c in poorly controlled T2D patients in a sub Saharan setting.
AB - Background: There is a burglar association between diabetes and periodontitis. Many studies has shown that periodontitis treatment can help improving glycemic control in diabetes patients but little evidence of non-surgical treatment benefit is available in sub Saharan african diabetes patients. We aimed to assess the effects of non-surgical periodontal treatment (NSPT) of chronic periodontitis on glycaemic control in poorly controlled type 2 diabetes patients (T2D) in a sub-Saharan Africa urban setting. Methods: A total of 34 poorly controlled T2D patients with chronic periodontitis aged 51.4±8.8years (mean±SD), with known duration of diabetes of 55.5±42.6months, and HbA1c of 9.3±1.3% were randomly assigned to two groups. The treatment group (Group 1, n=17) received immediate ultrasonic scaling, scaling and root planning along with subgingival 10% povidone iodine irrigation, whereas the control group (Group 2, n=17) was assigned to receive delayed periodontal treatment 3months later. Pharmacological treatment was unchanged and all participants received the same standardized education session on diabetes management and dental hygiene. The primary outcome was the 3-month change in HbA1c from baseline. Plaque index (PI), gingival bleeding index (GBI), pocket depth (PD), clinical attachment loss (CAL) were also assessed prior to, at 6 and 12weeks after enrolment. Results: Two subjects in each group were excluded from the study. Data were analyzed on thirty patients (15 per group). Non-surgical periodontal treatment with education for better dental hygiene (group 1) significantly improved all periodontal parameters whereas education only (group 2) improved only the plaque index among all periodontal parameters. Immediate non-surgical periodontal treatment induced a reduction of HbA1c levels by 3.0±2.4 points from 9.7±1.6% at baseline to 6.7±2.0% 3months after NSPT, (p 0.001) but the change was not significant in group 2, from mean 8.9±0.9% at baseline vs 8.1±2.6% after 3months (p=0.24). Conclusion: Non-surgical periodontal treatment markedly improved glycaemic control with an attributable reduction of 2.2 points of HbA1c in poorly controlled T2D patients in a sub Saharan setting.
KW - Diabetes
KW - Glycemic control
KW - HbA1c
KW - Inflammation
KW - Non-surgical periodontal treatment
KW - Periodontitis
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U2 - 10.1186/s12903-018-0479-5
DO - 10.1186/s12903-018-0479-5
M3 - Article
C2 - 29482543
AN - SCOPUS:85042530266
SN - 1472-6831
VL - 18
JO - BMC Oral Health
JF - BMC Oral Health
IS - 1
M1 - 28
ER -