Effects of hypoglycemia on human brain activation measured with fMRI

Adam W. Anderson; Rubina A. Heptulla; Naomi Driesen; Daniel Flanagan; Philip A. Goldberg; Timothy W. Jones; Fran Rife; Hedy Sarofin; William Tamborlane; Robert Sherwin; John C. Gore

doi:10.1016/j.mri.2006.03.013

Effects of hypoglycemia on human brain activation measured with fMRI

Adam W. Anderson
, Rubina A. Heptulla
, Naomi Driesen
, Daniel Flanagan
, Philip A. Goldberg
, Timothy W. Jones
, Fran Rife
, Hedy Sarofin
, William Tamborlane
, Robert Sherwin
, John C. Gore

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

Functional magnetic resonance imaging (fMRI) was used to measure the effects of acute hypoglycemia caused by passive sensory stimulation on brain activation. Visual stimulation was used to generate blood-oxygen-level-dependent (BOLD) contrast, which was monitored during hyperinsulinemic hypoglycemic and euglycemic clamp studies. Hypoglycemia (50±1 mg glucose/dl) decreased the fMRI signal relative to euglycemia in 10 healthy human subjects: the fractional signal change was reduced by 28±12% (P<.05). These changes were reversed when euglycemia was restored. These data provide a basis of comparison for studies that quantify hypoglycemia-related changes in fMRI activity during cognitive tasks based on visual stimuli and demonstrate that variations in blood glucose levels may modulate BOLD signals in the healthy brain.

Original language	English (US)
Pages (from-to)	693-697
Number of pages	5
Journal	Magnetic Resonance Imaging
Volume	24
Issue number	6
DOIs	https://doi.org/10.1016/j.mri.2006.03.013
State	Published - Jul 2006
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

BOLD effect
Functional MRI
Hypoglycemia
Visual cortex

ASJC Scopus subject areas

Biophysics
Biomedical Engineering
Radiology Nuclear Medicine and imaging

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10.1016/j.mri.2006.03.013

Cite this

@article{f1ca4ccf67714750ab3631d52ddd3033,

title = "Effects of hypoglycemia on human brain activation measured with fMRI",

abstract = "Functional magnetic resonance imaging (fMRI) was used to measure the effects of acute hypoglycemia caused by passive sensory stimulation on brain activation. Visual stimulation was used to generate blood-oxygen-level-dependent (BOLD) contrast, which was monitored during hyperinsulinemic hypoglycemic and euglycemic clamp studies. Hypoglycemia (50±1 mg glucose/dl) decreased the fMRI signal relative to euglycemia in 10 healthy human subjects: the fractional signal change was reduced by 28±12\% (P<.05). These changes were reversed when euglycemia was restored. These data provide a basis of comparison for studies that quantify hypoglycemia-related changes in fMRI activity during cognitive tasks based on visual stimuli and demonstrate that variations in blood glucose levels may modulate BOLD signals in the healthy brain.",

keywords = "BOLD effect, Functional MRI, Hypoglycemia, Visual cortex",

author = "Anderson, \{Adam W.\} and Heptulla, \{Rubina A.\} and Naomi Driesen and Daniel Flanagan and Goldberg, \{Philip A.\} and Jones, \{Timothy W.\} and Fran Rife and Hedy Sarofin and William Tamborlane and Robert Sherwin and Gore, \{John C.\}",

note = "Funding Information: This work was supported by grants from the Juvenile Diabetes Research Foundation and the National Institutes of Health (EB002326 and DK20495) and from the NCRR-funded Yale General Clinical Research Center (MO1-00125). ",

year = "2006",

month = jul,

doi = "10.1016/j.mri.2006.03.013",

language = "English (US)",

volume = "24",

pages = "693--697",

journal = "Magnetic Resonance Imaging",

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publisher = "Elsevier Inc.",

number = "6",

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TY - JOUR

T1 - Effects of hypoglycemia on human brain activation measured with fMRI

AU - Anderson, Adam W.

AU - Heptulla, Rubina A.

AU - Driesen, Naomi

AU - Flanagan, Daniel

AU - Goldberg, Philip A.

AU - Jones, Timothy W.

AU - Rife, Fran

AU - Sarofin, Hedy

AU - Tamborlane, William

AU - Sherwin, Robert

AU - Gore, John C.

N1 - Funding Information: This work was supported by grants from the Juvenile Diabetes Research Foundation and the National Institutes of Health (EB002326 and DK20495) and from the NCRR-funded Yale General Clinical Research Center (MO1-00125).

PY - 2006/7

Y1 - 2006/7

N2 - Functional magnetic resonance imaging (fMRI) was used to measure the effects of acute hypoglycemia caused by passive sensory stimulation on brain activation. Visual stimulation was used to generate blood-oxygen-level-dependent (BOLD) contrast, which was monitored during hyperinsulinemic hypoglycemic and euglycemic clamp studies. Hypoglycemia (50±1 mg glucose/dl) decreased the fMRI signal relative to euglycemia in 10 healthy human subjects: the fractional signal change was reduced by 28±12% (P<.05). These changes were reversed when euglycemia was restored. These data provide a basis of comparison for studies that quantify hypoglycemia-related changes in fMRI activity during cognitive tasks based on visual stimuli and demonstrate that variations in blood glucose levels may modulate BOLD signals in the healthy brain.

AB - Functional magnetic resonance imaging (fMRI) was used to measure the effects of acute hypoglycemia caused by passive sensory stimulation on brain activation. Visual stimulation was used to generate blood-oxygen-level-dependent (BOLD) contrast, which was monitored during hyperinsulinemic hypoglycemic and euglycemic clamp studies. Hypoglycemia (50±1 mg glucose/dl) decreased the fMRI signal relative to euglycemia in 10 healthy human subjects: the fractional signal change was reduced by 28±12% (P<.05). These changes were reversed when euglycemia was restored. These data provide a basis of comparison for studies that quantify hypoglycemia-related changes in fMRI activity during cognitive tasks based on visual stimuli and demonstrate that variations in blood glucose levels may modulate BOLD signals in the healthy brain.

KW - BOLD effect

KW - Functional MRI

KW - Hypoglycemia

KW - Visual cortex

UR - https://www.scopus.com/pages/publications/33745648727

UR - https://www.scopus.com/pages/publications/33745648727#tab=citedBy

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DO - 10.1016/j.mri.2006.03.013

M3 - Article

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AN - SCOPUS:33745648727

SN - 0730-725X

VL - 24

SP - 693

EP - 697

JO - Magnetic Resonance Imaging

JF - Magnetic Resonance Imaging

IS - 6

ER -

Effects of hypoglycemia on human brain activation measured with fMRI

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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