Abstract
The effects of alprazolam, a triazolobenzodiazepine, on hormonal and behavioral responses induced by meta-chlorophenylpiperazine (MCPP), a serotonin receptor agonist, were investigated in 10 healthy men. Alprazolam (0.5 mg) or placebo was given 1 hour before MCPP (0.5 mg/kg) or placebo. Cortisol, prolactin, and growth hormone (GH) release, MCPP and alprazolam plasma levels, anxiety level, and panic symptoms were measured over 210 minutes. MCPP was found to increase cortisol, prolactin, GH, and anxiety levels. Alprazolam decreased cortisol and GH levels but had no effect on prolactin. When used in combination with MCPP, alprazolam blunted MCPP-induced cortisol and GH release, and it blocked the anxiogenic effects of MCPP.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 219-229 |
| Number of pages | 11 |
| Journal | Psychiatry Research |
| Volume | 53 |
| Issue number | 3 |
| DOIs | |
| State | Published - Sep 1994 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Serotonin
- cortisol
- growth hormone
- prolactin
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry
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