Effectiveness of mRNA Vaccines Against COVID-19 Hospitalization by Age and Chronic Medical Conditions Burden Among Immunocompetent US Adults, March-August 2021

IVY Network Collaborators

doi:10.1093/infdis/jiab619

Effectiveness of mRNA Vaccines Against COVID-19 Hospitalization by Age and Chronic Medical Conditions Burden Among Immunocompetent US Adults, March-August 2021

IVY Network Collaborators

Medicine

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Vaccine effectiveness (VE) against COVID-19 hospitalization was evaluated among immunocompetent adults (≥18 years) during March-August 2021 using a case-control design. Among 1669 hospitalized COVID-19 cases (11% fully vaccinated) and 1950 RT-PCR-negative controls (54% fully vaccinated), VE was 96% (95% confidence interval [CI], 93%-98%) among patients with no chronic medical conditions and 83% (95% CI, 76%-88%) among patients with ≥ 3 categories of conditions. VE was similar between those aged 18-64 years versus ≥65 years (P >. 05). VE against severe COVID-19 was very high among adults without chronic conditions and lessened with increasing comorbidity burden.

Original language	English (US)
Pages (from-to)	1694-1700
Number of pages	7
Journal	Journal of Infectious Diseases
Volume	225
Issue number	10
DOIs	https://doi.org/10.1093/infdis/jiab619
State	Published - May 15 2022

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

COVID-19
chronic medical conditions
preexisting conditions
vaccine effectiveness

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

Access to Document

10.1093/infdis/jiab619

Cite this

@article{526b54e3f9934b2bbb5737c25e60cd23,

title = "Effectiveness of mRNA Vaccines Against COVID-19 Hospitalization by Age and Chronic Medical Conditions Burden Among Immunocompetent US Adults, March-August 2021",

abstract = "Vaccine effectiveness (VE) against COVID-19 hospitalization was evaluated among immunocompetent adults (≥18 years) during March-August 2021 using a case-control design. Among 1669 hospitalized COVID-19 cases (11\% fully vaccinated) and 1950 RT-PCR-negative controls (54\% fully vaccinated), VE was 96\% (95\% confidence interval [CI], 93\%-98\%) among patients with no chronic medical conditions and 83\% (95\% CI, 76\%-88\%) among patients with ≥ 3 categories of conditions. VE was similar between those aged 18-64 years versus ≥65 years (P >. 05). VE against severe COVID-19 was very high among adults without chronic conditions and lessened with increasing comorbidity burden.",

keywords = "COVID-19, chronic medical conditions, preexisting conditions, vaccine effectiveness",

author = "\{IVY Network Collaborators\} and Lewis, \{Nathaniel M.\} and Naioti, \{Eric A.\} and Self, \{Wesley H.\} and Ginde, \{Adit A.\} and Douin, \{David J.\} and \{Keipp Talbot\}, H. and Casey, \{Jonathan D.\} and Mohr, \{Nicholas M.\} and Anne Zepeski and Manjusha Gaglani and Ghamande, \{Shekhar A.\} and McNeal, \{Tresa A.\} and Shapiro, \{Nathan I.\} and Gibbs, \{Kevin W.\} and \{Clark Files\}, D. and Hager, \{David N.\} and Arber Shehu and Prekker, \{Matthew E.\} and Erickson, \{Heidi L.\} and Gong, \{Michelle N.\} and Amira Mohamed and Henning, \{Daniel J.\} and Steingrub, \{Jay S.\} and Peltan, \{Ithan D.\} and Brown, \{Samuel M.\} and Martin, \{Emily T.\} and Kinsley Hubel and Hough, \{Catherine L.\} and Busse, \{Laurence W.\} and \{Ten Lohuis\}, \{Caitlin C.\} and Abhijit Duggal and Wilson, \{Jennifer G.\} and Gordon, \{Alexandra J.\} and Nida Qadir and Chang, \{Steven Y.\} and Christopher Mallow and Carolina Rivas and Babcock, \{Hilary M.\} and Kwon, \{Jennie H.\} and Exline, \{Matthew C.\} and Natasha Halasa and Chappell, \{James D.\} and Lauring, \{Adam S.\} and Grijalva, \{Carlos G.\} and Rice, \{Todd W.\} and Rhoads, \{Jillian P.\} and Stubblefield, \{William B.\} and Adrienne Baughman and Chen, \{Jen Ting Tina\} and Hayley Gershengorn",

note = "Publisher Copyright: {\textcopyright} 2021 Published by Oxford University Press for the Infectious Diseases Society of America 2021.",

year = "2022",

month = may,

day = "15",

doi = "10.1093/infdis/jiab619",

language = "English (US)",

volume = "225",

pages = "1694--1700",

journal = "Journal of Infectious Diseases",

issn = "0022-1899",

publisher = "Oxford University Press",

number = "10",

}

TY - JOUR

T1 - Effectiveness of mRNA Vaccines Against COVID-19 Hospitalization by Age and Chronic Medical Conditions Burden Among Immunocompetent US Adults, March-August 2021

AU - IVY Network Collaborators

AU - Lewis, Nathaniel M.

AU - Naioti, Eric A.

AU - Self, Wesley H.

AU - Ginde, Adit A.

AU - Douin, David J.

AU - Keipp Talbot, H.

AU - Casey, Jonathan D.

AU - Mohr, Nicholas M.

AU - Zepeski, Anne

AU - Gaglani, Manjusha

AU - Ghamande, Shekhar A.

AU - McNeal, Tresa A.

AU - Shapiro, Nathan I.

AU - Gibbs, Kevin W.

AU - Clark Files, D.

AU - Hager, David N.

AU - Shehu, Arber

AU - Prekker, Matthew E.

AU - Erickson, Heidi L.

AU - Gong, Michelle N.

AU - Mohamed, Amira

AU - Henning, Daniel J.

AU - Steingrub, Jay S.

AU - Peltan, Ithan D.

AU - Brown, Samuel M.

AU - Martin, Emily T.

AU - Hubel, Kinsley

AU - Hough, Catherine L.

AU - Busse, Laurence W.

AU - Ten Lohuis, Caitlin C.

AU - Duggal, Abhijit

AU - Wilson, Jennifer G.

AU - Gordon, Alexandra J.

AU - Qadir, Nida

AU - Chang, Steven Y.

AU - Mallow, Christopher

AU - Rivas, Carolina

AU - Babcock, Hilary M.

AU - Kwon, Jennie H.

AU - Exline, Matthew C.

AU - Halasa, Natasha

AU - Chappell, James D.

AU - Lauring, Adam S.

AU - Grijalva, Carlos G.

AU - Rice, Todd W.

AU - Rhoads, Jillian P.

AU - Stubblefield, William B.

AU - Baughman, Adrienne

AU - Chen, Jen Ting Tina

AU - Gershengorn, Hayley

PY - 2022/5/15

Y1 - 2022/5/15

N2 - Vaccine effectiveness (VE) against COVID-19 hospitalization was evaluated among immunocompetent adults (≥18 years) during March-August 2021 using a case-control design. Among 1669 hospitalized COVID-19 cases (11% fully vaccinated) and 1950 RT-PCR-negative controls (54% fully vaccinated), VE was 96% (95% confidence interval [CI], 93%-98%) among patients with no chronic medical conditions and 83% (95% CI, 76%-88%) among patients with ≥ 3 categories of conditions. VE was similar between those aged 18-64 years versus ≥65 years (P >. 05). VE against severe COVID-19 was very high among adults without chronic conditions and lessened with increasing comorbidity burden.

AB - Vaccine effectiveness (VE) against COVID-19 hospitalization was evaluated among immunocompetent adults (≥18 years) during March-August 2021 using a case-control design. Among 1669 hospitalized COVID-19 cases (11% fully vaccinated) and 1950 RT-PCR-negative controls (54% fully vaccinated), VE was 96% (95% confidence interval [CI], 93%-98%) among patients with no chronic medical conditions and 83% (95% CI, 76%-88%) among patients with ≥ 3 categories of conditions. VE was similar between those aged 18-64 years versus ≥65 years (P >. 05). VE against severe COVID-19 was very high among adults without chronic conditions and lessened with increasing comorbidity burden.

KW - COVID-19

KW - chronic medical conditions

KW - preexisting conditions

KW - vaccine effectiveness

UR - https://www.scopus.com/pages/publications/85130645391

UR - https://www.scopus.com/pages/publications/85130645391#tab=citedBy

U2 - 10.1093/infdis/jiab619

DO - 10.1093/infdis/jiab619

M3 - Article

C2 - 34932114

AN - SCOPUS:85130645391

SN - 0022-1899

VL - 225

SP - 1694

EP - 1700

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 10

ER -

Effectiveness of mRNA Vaccines Against COVID-19 Hospitalization by Age and Chronic Medical Conditions Burden Among Immunocompetent US Adults, March-August 2021

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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