Effect of the number of biopsies on the subsequent acquisition of new human papillomavirus infections

Philip E. Castle, Nicolas Wentzensen, Cosette M. Wheeler, Greg Rydzak, Mark Schiffman

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


To analyze the effect of number of biopsies taken at enrollment with incident human papillomavirus (HPV) infections detected at the next 6-month visit. METHODS: Using data from the Atypical Squamous Cells of Undetermined Significance (ASCUS) and LowGrade Squamous Intraepithelial Lesion (LSIL) Triage Study (ALTS), we compared the 6-month acquisition of new HPV infections among 988 women who underwent colposcopy, were not diagnosed and treated for cervical intraepithelial neoplasia grade 2 or more severe lesions, and had polymerase chain reaction results for 38 HPV genotypes at enrollment and follow-up. Our analysis considered each woman's possible acquisition of each of these HPV genotypes. The average 6-month acquisition of any HPV genotype for women with zero, one, and two or more biopsies was 1.82%, 1.74%, and 1.97%, respectively Ctrend>7). In a logistic regression model that controlled for age, baseline HPV status, and having a new sexual partner during the 6-month follow-up, two or more biopsies (compared with one biopsy) was not associated with acquiring HPV (odds ratio 1.0, 95% confidence interval 0.75-1.3). Multiple biopsies compared with a single biopsy did not increase the likelihood of acquiring new HPV infections.

Original languageEnglish (US)
Pages (from-to)1057-1062
Number of pages6
JournalObstetrics and gynecology
Issue number5
StatePublished - Nov 2009
Externally publishedYes

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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