Effect of milrinone on steady-state digoxin levels in congestive heart failure

Kevin J. Ferrick, Aileen M. Ferrick, Steven A. Fein, Joseph T. Doyle

Research output: Contribution to journalArticlepeer-review


A variety of cardioactive agents have been shown to affect the pharmacokinetics of digoxin and thereby alter serum digoxin levels. Since the first reports describing the digoxin-quinidine interaction,1,2 numerous agents have been shown to increase serum digoxin levels.3-6 Milrinone is a nonglycoside, noncatecholamine inotropic agent currently undergoing investigation for the treatment of congestive heart failure. Because many patients receive digoxin for the treatment of heart failure, we attempted to determine retrospectively if milrinone significantly affects steady-state digoxin levels in a heart failure population.

Original languageEnglish (US)
Number of pages1
JournalThe American Journal of Cardiology
Issue number16
StatePublished - Nov 1 1989
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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