TY - JOUR
T1 - Effect of lung transplantation on heart rate response to exercise
AU - Armstrong, Hilary F.
AU - Gonzalez-Costello, Jose
AU - Thirapatarapong, Wilawan
AU - Jorde, Ulrich P.
AU - Bartels, Matthew N.
N1 - Funding Information:
The project described was supported by the Vidda Foundation . This publication was supported by the National Center for Advancing Translational Sciences , National Institutes of Health, through Grant Number UL1 TR000040 . The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.
Publisher Copyright:
© 2015 Elsevier Inc.
PY - 2015/5/1
Y1 - 2015/5/1
N2 - Objectives: To evaluate if patients have a change in percent of predicted heart rate reserve used at peak exercise (%HRR) after lung transplantation, even at matching workloads. Background: Lung disease of obstructive, restrictive, and mixed types may be associated with an autonomic imbalance. Lung transplantation may improve the effects of pulmonary disease on cardiac function. However, the effect of lung transplantation on heart rate responses during exercise has not been investigated in detail. Methods: Retrospective review of patients who underwent lung transplantation. Pre and post transplant cardiopulmonary exercise tests were reviewed. Results: The %HRR significantly improved by a median of 37% (. p<0.001) following lung transplantation. When matching workloads were analyzed, the %HRR also decreased from a median of 36% to 24% (. p<0.001). Conclusions: Corresponding to an increase in peak exercise capacity, percentage of heart rate reserve used improves significantly after lung transplantation, even at matching workloads, indicating a likely improvement in autonomic modulation.
AB - Objectives: To evaluate if patients have a change in percent of predicted heart rate reserve used at peak exercise (%HRR) after lung transplantation, even at matching workloads. Background: Lung disease of obstructive, restrictive, and mixed types may be associated with an autonomic imbalance. Lung transplantation may improve the effects of pulmonary disease on cardiac function. However, the effect of lung transplantation on heart rate responses during exercise has not been investigated in detail. Methods: Retrospective review of patients who underwent lung transplantation. Pre and post transplant cardiopulmonary exercise tests were reviewed. Results: The %HRR significantly improved by a median of 37% (. p<0.001) following lung transplantation. When matching workloads were analyzed, the %HRR also decreased from a median of 36% to 24% (. p<0.001). Conclusions: Corresponding to an increase in peak exercise capacity, percentage of heart rate reserve used improves significantly after lung transplantation, even at matching workloads, indicating a likely improvement in autonomic modulation.
KW - CPET
KW - Chronotropic incompetence
KW - Exercise
KW - Heart rate
KW - Lung transplantation
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U2 - 10.1016/j.hrtlng.2015.01.014
DO - 10.1016/j.hrtlng.2015.01.014
M3 - Article
C2 - 25869526
AN - SCOPUS:84929504535
SN - 0147-9563
VL - 44
SP - 246
EP - 250
JO - Heart and Lung: Journal of Acute and Critical Care
JF - Heart and Lung: Journal of Acute and Critical Care
IS - 3
ER -