Effect of amphotericin B on capsule and cell size in Cryptococcus neoformans during murine infection

Oscar Zaragoza; Coralia Mihu; Arturo Casadevall; Joshua D. Nosanchuk

doi:10.1128/AAC.49.10.4358-4361.2005

Effect of amphotericin B on capsule and cell size in Cryptococcus neoformans during murine infection

Oscar Zaragoza
, Coralia Mihu
, Arturo Casadevall
, Joshua D. Nosanchuk

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Antifungal drugs can affect the cellular morphology of Cryptococcus neoformans in culture, which alters its interactions with phagocytes. We examined the effects of amphotericin B on C. neoformans during murine infection. The antifungal reduced capsule size and serum polysaccharide, which suggests an additional mechanism for amphotericin B's efficacy in cryptococcosis.

Original language	English (US)
Pages (from-to)	4358-4361
Number of pages	4
Journal	Antimicrobial agents and chemotherapy
Volume	49
Issue number	10
DOIs	https://doi.org/10.1128/AAC.49.10.4358-4361.2005
State	Published - Oct 2005

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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10.1128/AAC.49.10.4358-4361.2005

Cite this

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title = "Effect of amphotericin B on capsule and cell size in Cryptococcus neoformans during murine infection",

abstract = "Antifungal drugs can affect the cellular morphology of Cryptococcus neoformans in culture, which alters its interactions with phagocytes. We examined the effects of amphotericin B on C. neoformans during murine infection. The antifungal reduced capsule size and serum polysaccharide, which suggests an additional mechanism for amphotericin B's efficacy in cryptococcosis.",

author = "Oscar Zaragoza and Coralia Mihu and Arturo Casadevall and Nosanchuk, \{Joshua D.\}",

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AU - Mihu, Coralia

AU - Casadevall, Arturo

AU - Nosanchuk, Joshua D.

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AB - Antifungal drugs can affect the cellular morphology of Cryptococcus neoformans in culture, which alters its interactions with phagocytes. We examined the effects of amphotericin B on C. neoformans during murine infection. The antifungal reduced capsule size and serum polysaccharide, which suggests an additional mechanism for amphotericin B's efficacy in cryptococcosis.

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UR - https://www.scopus.com/pages/publications/25844461959#tab=citedBy

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DO - 10.1128/AAC.49.10.4358-4361.2005

M3 - Article

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AN - SCOPUS:25844461959

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JF - Antimicrobial agents and chemotherapy

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ER -

Effect of amphotericin B on capsule and cell size in Cryptococcus neoformans during murine infection

Abstract

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