TY - JOUR
T1 - Effect of amphotericin B on capsule and cell size in Cryptococcus neoformans during murine infection
AU - Zaragoza, Oscar
AU - Mihu, Coralia
AU - Casadevall, Arturo
AU - Nosanchuk, Joshua D.
PY - 2005/10
Y1 - 2005/10
N2 - Antifungal drugs can affect the cellular morphology of Cryptococcus neoformans in culture, which alters its interactions with phagocytes. We examined the effects of amphotericin B on C. neoformans during murine infection. The antifungal reduced capsule size and serum polysaccharide, which suggests an additional mechanism for amphotericin B's efficacy in cryptococcosis.
AB - Antifungal drugs can affect the cellular morphology of Cryptococcus neoformans in culture, which alters its interactions with phagocytes. We examined the effects of amphotericin B on C. neoformans during murine infection. The antifungal reduced capsule size and serum polysaccharide, which suggests an additional mechanism for amphotericin B's efficacy in cryptococcosis.
UR - http://www.scopus.com/inward/record.url?scp=25844461959&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=25844461959&partnerID=8YFLogxK
U2 - 10.1128/AAC.49.10.4358-4361.2005
DO - 10.1128/AAC.49.10.4358-4361.2005
M3 - Article
C2 - 16189121
AN - SCOPUS:25844461959
SN - 0066-4804
VL - 49
SP - 4358
EP - 4361
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 10
ER -
