Effect of a stepwise opioid-sparing analgesic protocol on in-hospital oxycodone use and discharge prescription after cesarean delivery

Ruth Landau, Erik Romanelli, Bahaa Daoud, Ben Shatil, Xiwen Zheng, Beatrice Corradini, Janice Aubey, Caroline Wu, Catherine Ha, Jean Guglielminotti

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Introduction Opioid exposure during hospitalization for cesarean delivery increases the risk of new persistent opioid use. We studied the effectiveness of stepwise multimodal opioid-sparing analgesia in reducing oxycodone use during cesarean delivery hospitalization and prescriptions at discharge. Methods This retrospective cohort study analyzed electronic health records of consecutive cesarean delivery cases in four academic hospitals in a large metropolitan area, before and after implementation of a stepwise multimodal opioid-sparing analgesic computerized order set coupled with provider education. The primary outcome was the proportion of women not using any oxycodone during in-hospital stay (â € non-oxycodone user'). In-hospital secondary outcomes were: (1) total in-hospital oxycodone dose among users, and (2) time to first oxycodone pill. Discharge secondary outcomes were: (1) proportion of oxycodone-free discharge prescription, and (2) number of oxycodone pills prescribed. Results The intervention was associated with a significant increase in the proportion of non-oxycodone users from 15% to 32% (17% difference; 95% CI 10 to 25), a decrease in total in-hospital oxycodone dose among users, and no change in the time to first oxycodone dose. The adjusted OR for being a non-oxycodone user associated with the intervention was 2.67 (95% CI 2.12 to 3.50). With the intervention, the proportion of oxycodone-free discharge prescription increased from 4.4% to 8.5% (4.1% difference; 95% CI 2.5 to 5.6) and the number of prescribed oxycodone pills decreased from 30 to 18 (-12 pills difference; 95% CI-11 to-13). Conclusions Multimodal stepwise analgesia after cesarean delivery increases the proportion of oxycodone-free women during in-hospital stay and at discharge.

Original languageEnglish (US)
Pages (from-to)151-156
Number of pages6
JournalRegional anesthesia and pain medicine
Issue number2
StatePublished - Feb 1 2021


  • analgesics
  • health care
  • obstetrics
  • opioid
  • outcome assessment

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


Dive into the research topics of 'Effect of a stepwise opioid-sparing analgesic protocol on in-hospital oxycodone use and discharge prescription after cesarean delivery'. Together they form a unique fingerprint.

Cite this