Abstract
Purpose: Clinical studies suggest a correlation between changes in activity of the contralesional cerebral cortex and spontaneous recovery from stroke, but whether this is a causal relationship is uncertain. Methods: Young adult Sprague-Dawley male rats underwent unilateral or bilateral permanent distal middle cerebral artery occlusion (dMCAO). Infarct volume was determined by 2,3,5-triphenyltetrazolium chloride (TTC) staining 24 hr after dMCAO, and functional outcome was assessed 1-28 days after dMCAO using the ladder rung walking and limb placing tests. Results: Infarct volume was unchanged, but functional neurological deficits were reduced 1 day after bilateral compared to unilateral dMCAO. Conclusions: Activity in the contralesional cerebral cortex may inhibit functional motor recovery after experimental stroke.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 491-495 |
| Number of pages | 5 |
| Journal | Restorative Neurology and Neuroscience |
| Volume | 30 |
| Issue number | 6 |
| DOIs | |
| State | Published - 2012 |
| Externally published | Yes |
Keywords
- Stroke
- ischemia
- rat
- recovery
ASJC Scopus subject areas
- Neurology
- Developmental Neuroscience
- Clinical Neurology