EEG alpha power changes reflect response inhibition deficits after traumatic brain injury (TBI) in humans

Richard A.P. Roche; Paul M. Dockree; Hugh Garavan; John J. Foxe; Ian H. Robertson; Shane M. O'Mara

doi:10.1016/j.neulet.2003.11.064

EEG alpha power changes reflect response inhibition deficits after traumatic brain injury (TBI) in humans

Richard A.P. Roche, Paul M. Dockree, Hugh Garavan, John J. Foxe, Ian H. Robertson, Shane M. O'Mara

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

Brain damage due to traumatic brain injury (TBI) has been associated with deficits in executive functions and the dynamic control of behaviour. Event-related brain potentials and spectral power data were recorded from eight TBI participants and eight matched controls while they completed a Go/NoGo response inhibition task. The TBI group was found to be significantly impaired at the task compared to controls, and exhibited abnormal N2 and P3 waveform components in response to NoGo stimuli relative to controls. Significant correlations were also found between alpha power, Go-trial RT and errors. We conclude that abnormal activity in the structures damaged in this group may render such patients less capable of maintaining a state of alpha desynchronisation compared to controls, resulting in poorer performance on the task.

Original language	English (US)
Pages (from-to)	1-5
Number of pages	5
Journal	Neuroscience Letters
Volume	362
Issue number	1
DOIs	https://doi.org/10.1016/j.neulet.2003.11.064
State	Published - May 13 2004
Externally published	Yes

Keywords

Desynchronisation
Event-related potentials
Inhibitory control
N2/P3 complex
Spectral power

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.neulet.2003.11.064

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title = "EEG alpha power changes reflect response inhibition deficits after traumatic brain injury (TBI) in humans",

abstract = "Brain damage due to traumatic brain injury (TBI) has been associated with deficits in executive functions and the dynamic control of behaviour. Event-related brain potentials and spectral power data were recorded from eight TBI participants and eight matched controls while they completed a Go/NoGo response inhibition task. The TBI group was found to be significantly impaired at the task compared to controls, and exhibited abnormal N2 and P3 waveform components in response to NoGo stimuli relative to controls. Significant correlations were also found between alpha power, Go-trial RT and errors. We conclude that abnormal activity in the structures damaged in this group may render such patients less capable of maintaining a state of alpha desynchronisation compared to controls, resulting in poorer performance on the task.",

keywords = "Desynchronisation, Event-related potentials, Inhibitory control, N2/P3 complex, Spectral power",

author = "Roche, {Richard A.P.} and Dockree, {Paul M.} and Hugh Garavan and Foxe, {John J.} and Robertson, {Ian H.} and O'Mara, {Shane M.}",

note = "Funding Information: This work was supported by Enterprise Ireland; S.M. O'Mara was in receipt of a Berkeley Fellowship from Trinity College (2000–2001). H. Garavan was in receipt of NIDA support: DA14100. Thanks go to Deirdre Foxe and Glenn Wylie at NKI for their assistance with ERP analyses. Special thanks go to our participants for their patience and cooperation, to Miguel Angel Rodriguez at Medtech for technical assistance, to Kevin Murphy (Trinity College) for writing the program, and to those at Headway Ireland.",

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AU - Roche, Richard A.P.

AU - Dockree, Paul M.

AU - Garavan, Hugh

AU - Foxe, John J.

AU - Robertson, Ian H.

AU - O'Mara, Shane M.

N1 - Funding Information: This work was supported by Enterprise Ireland; S.M. O'Mara was in receipt of a Berkeley Fellowship from Trinity College (2000–2001). H. Garavan was in receipt of NIDA support: DA14100. Thanks go to Deirdre Foxe and Glenn Wylie at NKI for their assistance with ERP analyses. Special thanks go to our participants for their patience and cooperation, to Miguel Angel Rodriguez at Medtech for technical assistance, to Kevin Murphy (Trinity College) for writing the program, and to those at Headway Ireland.

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N2 - Brain damage due to traumatic brain injury (TBI) has been associated with deficits in executive functions and the dynamic control of behaviour. Event-related brain potentials and spectral power data were recorded from eight TBI participants and eight matched controls while they completed a Go/NoGo response inhibition task. The TBI group was found to be significantly impaired at the task compared to controls, and exhibited abnormal N2 and P3 waveform components in response to NoGo stimuli relative to controls. Significant correlations were also found between alpha power, Go-trial RT and errors. We conclude that abnormal activity in the structures damaged in this group may render such patients less capable of maintaining a state of alpha desynchronisation compared to controls, resulting in poorer performance on the task.

AB - Brain damage due to traumatic brain injury (TBI) has been associated with deficits in executive functions and the dynamic control of behaviour. Event-related brain potentials and spectral power data were recorded from eight TBI participants and eight matched controls while they completed a Go/NoGo response inhibition task. The TBI group was found to be significantly impaired at the task compared to controls, and exhibited abnormal N2 and P3 waveform components in response to NoGo stimuli relative to controls. Significant correlations were also found between alpha power, Go-trial RT and errors. We conclude that abnormal activity in the structures damaged in this group may render such patients less capable of maintaining a state of alpha desynchronisation compared to controls, resulting in poorer performance on the task.

KW - Desynchronisation

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KW - Inhibitory control

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KW - Spectral power

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EEG alpha power changes reflect response inhibition deficits after traumatic brain injury (TBI) in humans

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Keywords

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