Educational case: Endocrine neoplasm: Medullary thyroid carcinoma

Sheila Segura; Gloria Ramos-Rivera; Mark Suhrland

doi:10.1177/2374289518775722

Educational case: Endocrine neoplasm: Medullary thyroid carcinoma

Sheila Segura, Gloria Ramos-Rivera, Mark Suhrland

Pathology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Medullary thyroid cancer is a rare neuroendocrine tumor that arises the neural crest-derived parafollicular C cells and accounts for approximately 5% to 10% of thyroid cancers worldwide. These tumor can occur sporadically or as part of hereditary tumor syndromes, such as multiple endocrine neoplasia 2 and familial medullary thyroid cancer. The most common clinical presentation is a solitary thyroid nodule. The genetic defect in these disorders involves the RET proto-oncogene which is important for diagnosis of medullary thyroid cancer (including screening for hereditary medullary thyroid cancer) and for treatment guidance.This review summarizes the molecular basis and clinicopathologic features of medullary thyroid carcinoma.

Original language	English (US)
Journal	Academic Pathology
Volume	5
DOIs	https://doi.org/10.1177/2374289518775722
State	Published - Jan 1 2018

Keywords

Clinical features
Cytologic diagnosis
Endocrine neoplasms
Medullary thyroid carcinoma
Molecular basis
Organ system pathology
Pathologic features
Pathology competencies

ASJC Scopus subject areas

Pathology and Forensic Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1177/2374289518775722

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title = "Educational case: Endocrine neoplasm: Medullary thyroid carcinoma",

abstract = "Medullary thyroid cancer is a rare neuroendocrine tumor that arises the neural crest-derived parafollicular C cells and accounts for approximately 5% to 10% of thyroid cancers worldwide. These tumor can occur sporadically or as part of hereditary tumor syndromes, such as multiple endocrine neoplasia 2 and familial medullary thyroid cancer. The most common clinical presentation is a solitary thyroid nodule. The genetic defect in these disorders involves the RET proto-oncogene which is important for diagnosis of medullary thyroid cancer (including screening for hereditary medullary thyroid cancer) and for treatment guidance.This review summarizes the molecular basis and clinicopathologic features of medullary thyroid carcinoma.",

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AU - Ramos-Rivera, Gloria

AU - Suhrland, Mark

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N2 - Medullary thyroid cancer is a rare neuroendocrine tumor that arises the neural crest-derived parafollicular C cells and accounts for approximately 5% to 10% of thyroid cancers worldwide. These tumor can occur sporadically or as part of hereditary tumor syndromes, such as multiple endocrine neoplasia 2 and familial medullary thyroid cancer. The most common clinical presentation is a solitary thyroid nodule. The genetic defect in these disorders involves the RET proto-oncogene which is important for diagnosis of medullary thyroid cancer (including screening for hereditary medullary thyroid cancer) and for treatment guidance.This review summarizes the molecular basis and clinicopathologic features of medullary thyroid carcinoma.

AB - Medullary thyroid cancer is a rare neuroendocrine tumor that arises the neural crest-derived parafollicular C cells and accounts for approximately 5% to 10% of thyroid cancers worldwide. These tumor can occur sporadically or as part of hereditary tumor syndromes, such as multiple endocrine neoplasia 2 and familial medullary thyroid cancer. The most common clinical presentation is a solitary thyroid nodule. The genetic defect in these disorders involves the RET proto-oncogene which is important for diagnosis of medullary thyroid cancer (including screening for hereditary medullary thyroid cancer) and for treatment guidance.This review summarizes the molecular basis and clinicopathologic features of medullary thyroid carcinoma.

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KW - Cytologic diagnosis

KW - Endocrine neoplasms

KW - Medullary thyroid carcinoma

KW - Molecular basis

KW - Organ system pathology

KW - Pathologic features

KW - Pathology competencies

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Educational case: Endocrine neoplasm: Medullary thyroid carcinoma

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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