Educational case: Endocrine neoplasm: Medullary thyroid carcinoma

Sheila Segura, Gloria Ramos-Rivera, Mark Suhrland

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Medullary thyroid cancer is a rare neuroendocrine tumor that arises the neural crest-derived parafollicular C cells and accounts for approximately 5% to 10% of thyroid cancers worldwide. These tumor can occur sporadically or as part of hereditary tumor syndromes, such as multiple endocrine neoplasia 2 and familial medullary thyroid cancer. The most common clinical presentation is a solitary thyroid nodule. The genetic defect in these disorders involves the RET proto-oncogene which is important for diagnosis of medullary thyroid cancer (including screening for hereditary medullary thyroid cancer) and for treatment guidance.This review summarizes the molecular basis and clinicopathologic features of medullary thyroid carcinoma.

Original languageEnglish (US)
JournalAcademic Pathology
StatePublished - Jan 1 2018


  • Clinical features
  • Cytologic diagnosis
  • Endocrine neoplasms
  • Medullary thyroid carcinoma
  • Molecular basis
  • Organ system pathology
  • Pathologic features
  • Pathology competencies

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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