E Proteins and ID Proteins: Helix-Loop-Helix Partners in Development and Disease

Lan Hsin Wang; Nicholas E. Baker

doi:10.1016/j.devcel.2015.10.019

E Proteins and ID Proteins: Helix-Loop-Helix Partners in Development and Disease

Lan Hsin Wang, Nicholas E. Baker

Research output: Contribution to journal › Review article › peer-review

100 Scopus citations

Abstract

The basic Helix-Loop-Helix (bHLH) proteins represent a well-known class of transcriptional regulators. Many bHLH proteins act as heterodimers with members of a class of ubiquitous partners, the E proteins. A widely expressed class of inhibitory heterodimer partners-the Inhibitor of DNA-binding (ID) proteins-also exists. Genetic and molecular analyses in humans and in knockout mice implicate E proteins and ID proteins in a wide variety of diseases, belying the notion that they are non-specific partner proteins. Here, we explore relationships of E proteins and ID proteins to a variety of disease processes and highlight gaps in knowledge of disease mechanisms.

Original language	English (US)
Pages (from-to)	269-280
Number of pages	12
Journal	Developmental cell
Volume	35
Issue number	3
DOIs	https://doi.org/10.1016/j.devcel.2015.10.019
State	Published - Nov 9 2015

Keywords

Arterial vascular disease
Atherosclerosis
Cell-cycle regulation
Cellular senescence
Congenital hydronephrosis
Development
Diabetes
Differentiation
Disease
E protein
Fuchs corneal dystrophy
Helix-Loop-Helix protein
ID protein
Mammary gland
Neuronal morphogenesis
Osteoporosis
Parkinson's disease
Pitt-Hopkins syndrome
Pulmonary arterial hypertension
Rett syndrome
Schizophrenia
Sertoli cell
Sjogren's syndrome
Trophoblast

ASJC Scopus subject areas

Molecular Biology
Biochemistry, Genetics and Molecular Biology(all)
Developmental Biology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.devcel.2015.10.019

Cite this

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title = "E Proteins and ID Proteins: Helix-Loop-Helix Partners in Development and Disease",

abstract = "The basic Helix-Loop-Helix (bHLH) proteins represent a well-known class of transcriptional regulators. Many bHLH proteins act as heterodimers with members of a class of ubiquitous partners, the E proteins. A widely expressed class of inhibitory heterodimer partners-the Inhibitor of DNA-binding (ID) proteins-also exists. Genetic and molecular analyses in humans and in knockout mice implicate E proteins and ID proteins in a wide variety of diseases, belying the notion that they are non-specific partner proteins. Here, we explore relationships of E proteins and ID proteins to a variety of disease processes and highlight gaps in knowledge of disease mechanisms.",

keywords = "Arterial vascular disease, Atherosclerosis, Cell-cycle regulation, Cellular senescence, Congenital hydronephrosis, Development, Diabetes, Differentiation, Disease, E protein, Fuchs corneal dystrophy, Helix-Loop-Helix protein, ID protein, Mammary gland, Neuronal morphogenesis, Osteoporosis, Parkinson's disease, Pitt-Hopkins syndrome, Pulmonary arterial hypertension, Rett syndrome, Schizophrenia, Sertoli cell, Sjogren's syndrome, Trophoblast",

author = "Wang, {Lan Hsin} and Baker, {Nicholas E.}",

note = "Funding Information: We thank A. Bhattacharya and K. Li for contributions to work on HLH proteins in our laboratory and J. Hebert, H. Lachman, B. Morrow, N. Sibinga, and the anonymous reviewers for comments on the manuscript. Our work on HLH proteins is supported by the NIH (GM047892) and by an Unrestricted Grant from Research to Prevent Blindness to the Department of Ophthalmology and Visual Sciences. Publisher Copyright: {\textcopyright} 2015 Elsevier Inc.",

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N2 - The basic Helix-Loop-Helix (bHLH) proteins represent a well-known class of transcriptional regulators. Many bHLH proteins act as heterodimers with members of a class of ubiquitous partners, the E proteins. A widely expressed class of inhibitory heterodimer partners-the Inhibitor of DNA-binding (ID) proteins-also exists. Genetic and molecular analyses in humans and in knockout mice implicate E proteins and ID proteins in a wide variety of diseases, belying the notion that they are non-specific partner proteins. Here, we explore relationships of E proteins and ID proteins to a variety of disease processes and highlight gaps in knowledge of disease mechanisms.

AB - The basic Helix-Loop-Helix (bHLH) proteins represent a well-known class of transcriptional regulators. Many bHLH proteins act as heterodimers with members of a class of ubiquitous partners, the E proteins. A widely expressed class of inhibitory heterodimer partners-the Inhibitor of DNA-binding (ID) proteins-also exists. Genetic and molecular analyses in humans and in knockout mice implicate E proteins and ID proteins in a wide variety of diseases, belying the notion that they are non-specific partner proteins. Here, we explore relationships of E proteins and ID proteins to a variety of disease processes and highlight gaps in knowledge of disease mechanisms.

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KW - Atherosclerosis

KW - Cell-cycle regulation

KW - Cellular senescence

KW - Congenital hydronephrosis

KW - Development

KW - Diabetes

KW - Differentiation

KW - Disease

KW - E protein

KW - Fuchs corneal dystrophy

KW - Helix-Loop-Helix protein

KW - ID protein

KW - Mammary gland

KW - Neuronal morphogenesis

KW - Osteoporosis

KW - Parkinson's disease

KW - Pitt-Hopkins syndrome

KW - Pulmonary arterial hypertension

KW - Rett syndrome

KW - Schizophrenia

KW - Sertoli cell

KW - Sjogren's syndrome

KW - Trophoblast

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E Proteins and ID Proteins: Helix-Loop-Helix Partners in Development and Disease

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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