Dysfunctional mitochondria elicit bioenergetic decline in the aged heart

Pasquale Mone; Esther Densu Agyapong; Giampaolo Morciano; Stanislovas S. Jankauskas; Antonio De Luca; Fahimeh Varzideh; Paolo Pinton; Gaetano Santulli

doi:10.20517/jca.2023.50

Dysfunctional mitochondria elicit bioenergetic decline in the aged heart

Pasquale Mone, Esther Densu Agyapong, Giampaolo Morciano, Stanislovas S. Jankauskas, Antonio De Luca, Fahimeh Varzideh, Paolo Pinton, Gaetano Santulli

Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

Aging represents a complex biological progression affecting the entire body, marked by a gradual decline in tissue function, rendering organs more susceptible to stress and diseases. The human heart holds significant importance in this context, as its aging process poses life-threatening risks. It entails macroscopic morphological shifts and biochemical changes that collectively contribute to diminished cardiac function. Among the numerous pivotal factors in aging, mitochondria play a critical role, intersecting with various molecular pathways and housing several aging-related agents. In this comprehensive review, we provide an updated overview of the functional role of mitochondria in cardiac aging.

Original language	English (US)
Article number	13
Journal	Journal of Cardiovascular Aging
Volume	4
Issue number	2
DOIs	https://doi.org/10.20517/jca.2023.50
State	Published - 2024

Keywords

Autophagy
RAAS
ROS
cardiac aging
fibrosis
mitochondria
mitophagy
neurohormonal systems
oxidative stress
sympathetic nervous system

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.20517/jca.2023.50

Cite this

@article{54415211864344e9918089b56ad813af,

title = "Dysfunctional mitochondria elicit bioenergetic decline in the aged heart",

abstract = "Aging represents a complex biological progression affecting the entire body, marked by a gradual decline in tissue function, rendering organs more susceptible to stress and diseases. The human heart holds significant importance in this context, as its aging process poses life-threatening risks. It entails macroscopic morphological shifts and biochemical changes that collectively contribute to diminished cardiac function. Among the numerous pivotal factors in aging, mitochondria play a critical role, intersecting with various molecular pathways and housing several aging-related agents. In this comprehensive review, we provide an updated overview of the functional role of mitochondria in cardiac aging.",

keywords = "Autophagy, RAAS, ROS, cardiac aging, fibrosis, mitochondria, mitophagy, neurohormonal systems, oxidative stress, sympathetic nervous system",

author = "Pasquale Mone and Agyapong, {Esther Densu} and Giampaolo Morciano and Jankauskas, {Stanislovas S.} and Luca, {Antonio De} and Fahimeh Varzideh and Paolo Pinton and Gaetano Santulli",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2024.",

year = "2024",

doi = "10.20517/jca.2023.50",

language = "English (US)",

volume = "4",

journal = "Journal of Cardiovascular Aging",

issn = "2768-5993",

publisher = "OAE Publishing Inc.",

number = "2",

}

TY - JOUR

T1 - Dysfunctional mitochondria elicit bioenergetic decline in the aged heart

AU - Mone, Pasquale

AU - Agyapong, Esther Densu

AU - Morciano, Giampaolo

AU - Jankauskas, Stanislovas S.

AU - Luca, Antonio De

AU - Varzideh, Fahimeh

AU - Pinton, Paolo

AU - Santulli, Gaetano

N1 - Publisher Copyright: © The Author(s) 2024.

PY - 2024

Y1 - 2024

N2 - Aging represents a complex biological progression affecting the entire body, marked by a gradual decline in tissue function, rendering organs more susceptible to stress and diseases. The human heart holds significant importance in this context, as its aging process poses life-threatening risks. It entails macroscopic morphological shifts and biochemical changes that collectively contribute to diminished cardiac function. Among the numerous pivotal factors in aging, mitochondria play a critical role, intersecting with various molecular pathways and housing several aging-related agents. In this comprehensive review, we provide an updated overview of the functional role of mitochondria in cardiac aging.

AB - Aging represents a complex biological progression affecting the entire body, marked by a gradual decline in tissue function, rendering organs more susceptible to stress and diseases. The human heart holds significant importance in this context, as its aging process poses life-threatening risks. It entails macroscopic morphological shifts and biochemical changes that collectively contribute to diminished cardiac function. Among the numerous pivotal factors in aging, mitochondria play a critical role, intersecting with various molecular pathways and housing several aging-related agents. In this comprehensive review, we provide an updated overview of the functional role of mitochondria in cardiac aging.

KW - Autophagy

KW - RAAS

KW - ROS

KW - cardiac aging

KW - fibrosis

KW - mitochondria

KW - mitophagy

KW - neurohormonal systems

KW - oxidative stress

KW - sympathetic nervous system

UR - http://www.scopus.com/inward/record.url?scp=85184735033&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85184735033&partnerID=8YFLogxK

U2 - 10.20517/jca.2023.50

DO - 10.20517/jca.2023.50

M3 - Review article

AN - SCOPUS:85184735033

SN - 2768-5993

VL - 4

JO - Journal of Cardiovascular Aging

JF - Journal of Cardiovascular Aging

IS - 2

M1 - 13

ER -

Dysfunctional mitochondria elicit bioenergetic decline in the aged heart

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this