Duplication and triplication of der(21)t(8;21)(q22;q22) in acute myeloid leukemia

Michael Mikulasovich; Amanda LeBlanc; Angela Scalise; Deepa Manwani; Alla Keyzner; Vesna Najfeld

doi:10.1016/j.cancergencyto.2008.10.004

Duplication and triplication of der(21)t(8;21)(q22;q22) in acute myeloid leukemia

Michael Mikulasovich
, Amanda LeBlanc
, Angela Scalise
, Deepa Manwani
, Alla Keyzner
, Vesna Najfeld

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

We report on two patients with complicons resulting in duplication der(21)t(8;21)(q22;q22), triplication in the form of isochromosome of der(21)t(8;21), and four copies of ETO-AML1 fusion. Duplication of der(21) was present at diagnosis as a minor cell population in one patient, while the presence of isoderivative (21)t(8;21) characterized the relapse cells of the second patient. Due to the rarity of these cases, literature search of other reported cases of complicons may be taken as evidence that duplication and triplication of ETO-AML1 may be a poor prognostic indicator, regardless of whether it is present at diagnosis or relapse.

Original language	English (US)
Pages (from-to)	83-87
Number of pages	5
Journal	Cancer Genetics and Cytogenetics
Volume	188
Issue number	2
DOIs	https://doi.org/10.1016/j.cancergencyto.2008.10.004
State	Published - Jan 15 2009
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

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10.1016/j.cancergencyto.2008.10.004

Cite this

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title = "Duplication and triplication of der(21)t(8;21)(q22;q22) in acute myeloid leukemia",

abstract = "We report on two patients with complicons resulting in duplication der(21)t(8;21)(q22;q22), triplication in the form of isochromosome of der(21)t(8;21), and four copies of ETO-AML1 fusion. Duplication of der(21) was present at diagnosis as a minor cell population in one patient, while the presence of isoderivative (21)t(8;21) characterized the relapse cells of the second patient. Due to the rarity of these cases, literature search of other reported cases of complicons may be taken as evidence that duplication and triplication of ETO-AML1 may be a poor prognostic indicator, regardless of whether it is present at diagnosis or relapse.",

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AU - Mikulasovich, Michael

AU - LeBlanc, Amanda

AU - Scalise, Angela

AU - Manwani, Deepa

AU - Keyzner, Alla

AU - Najfeld, Vesna

PY - 2009/1/15

Y1 - 2009/1/15

N2 - We report on two patients with complicons resulting in duplication der(21)t(8;21)(q22;q22), triplication in the form of isochromosome of der(21)t(8;21), and four copies of ETO-AML1 fusion. Duplication of der(21) was present at diagnosis as a minor cell population in one patient, while the presence of isoderivative (21)t(8;21) characterized the relapse cells of the second patient. Due to the rarity of these cases, literature search of other reported cases of complicons may be taken as evidence that duplication and triplication of ETO-AML1 may be a poor prognostic indicator, regardless of whether it is present at diagnosis or relapse.

AB - We report on two patients with complicons resulting in duplication der(21)t(8;21)(q22;q22), triplication in the form of isochromosome of der(21)t(8;21), and four copies of ETO-AML1 fusion. Duplication of der(21) was present at diagnosis as a minor cell population in one patient, while the presence of isoderivative (21)t(8;21) characterized the relapse cells of the second patient. Due to the rarity of these cases, literature search of other reported cases of complicons may be taken as evidence that duplication and triplication of ETO-AML1 may be a poor prognostic indicator, regardless of whether it is present at diagnosis or relapse.

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JO - Cancer Genetics and Cytogenetics

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IS - 2

ER -

Duplication and triplication of der(21)t(8;21)(q22;q22) in acute myeloid leukemia

Abstract

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