TY - JOUR
T1 - Dual trajectories of antiretroviral therapy adherence and polypharmacy in women with HIV in the United States
AU - Elbur, Abubaker Ibrahim
AU - Ghebremichael, Musie
AU - Konkle-Parker, Deborah
AU - Jones, Deborah L.
AU - Collins, Shelby
AU - Adimora, Adaora A.
AU - Schneider, Michael F.
AU - Cohen, Mardge H.
AU - Tamraz, Bani
AU - Plankey, Michael
AU - Wilson, Tracey
AU - Adedimeji, Adebola
AU - Haberer, Jessica E.
AU - Jacobson, Denise L.
N1 - Publisher Copyright:
© 2023, The Author(s).
PY - 2023/12
Y1 - 2023/12
N2 - Background: Polypharmacy, using five or more medications, may increase the risk of nonadherence to prescribed treatment. We aimed to identify the interrelationship between trajectories of adherence to antiretroviral therapy (ART) and polypharmacy. Methods: We included women with HIV (aged ≥ 18) enrolled in the Women’s Interagency HIV Study in the United States from 2014 to 2019. We used group-based trajectory modeling (GBTM) to identify trajectories of adherence to ART and polypharmacy and the dual GBTM to identify the interrelationship between adherence and polypharmacy. Results: Overall, 1,538 were eligible (median age of 49 years). GBTM analysis revealed five latent trajectories of adherence with 42% of women grouped in the consistently moderate trajectory. GBTM identified four polypharmacy trajectories with 45% categorized in the consistently low group. Conclusions: The joint model did not reveal any interrelationship between ART adherence and polypharmacy trajectories. Future research should consider examining the interrelationship between both variables using objective measures of adherence.
AB - Background: Polypharmacy, using five or more medications, may increase the risk of nonadherence to prescribed treatment. We aimed to identify the interrelationship between trajectories of adherence to antiretroviral therapy (ART) and polypharmacy. Methods: We included women with HIV (aged ≥ 18) enrolled in the Women’s Interagency HIV Study in the United States from 2014 to 2019. We used group-based trajectory modeling (GBTM) to identify trajectories of adherence to ART and polypharmacy and the dual GBTM to identify the interrelationship between adherence and polypharmacy. Results: Overall, 1,538 were eligible (median age of 49 years). GBTM analysis revealed five latent trajectories of adherence with 42% of women grouped in the consistently moderate trajectory. GBTM identified four polypharmacy trajectories with 45% categorized in the consistently low group. Conclusions: The joint model did not reveal any interrelationship between ART adherence and polypharmacy trajectories. Future research should consider examining the interrelationship between both variables using objective measures of adherence.
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U2 - 10.1186/s12981-023-00520-4
DO - 10.1186/s12981-023-00520-4
M3 - Article
C2 - 37179294
AN - SCOPUS:85159738689
SN - 1742-6405
VL - 20
JO - AIDS Research and Therapy
JF - AIDS Research and Therapy
IS - 1
M1 - 29
ER -
