Drug-eluting balloon versus second-generation drug-eluting stent for the treatment of restenotic lesions involving coronary bifurcations

Toru Naganuma, Azeem Latib, Charis Costopoulos, Jacopo Oreglia, Luca Testa, Federico De Marco, Alessandro Candreva, Alaide Chieffo, Charbel Naim, Matteo Montorfano, Francesco Bedogni, Antonio Colombo

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Aims: To report clinical outcomes in patients treated with drug-eluting balloon (DEB) versus second-generation drug-eluting stent (DES) for in-stent restenosis (ISR) involving a bifurcation lesion. Methods and results: Between February 2007 and November 2012, 167 bifurcation restenoses in 158 patients were treated with either DEB (n=73) or second-generation DES (n=85). The EuroSCORE was significantly higher in the DEB group (4.2±3.8 vs. 2.8±2.1, p=0.004). Regarding restenosed stent type, second- generation DES was more frequently seen in the DEB group (26.9% vs. 6.7%, p<0.001). In this group, there was also a trend towards more frequent stenting for a previous ISR (stent-in-stent) as compared with the DES group (25.6% vs. 15.6%, p=0.074). Over a median follow-up period of 701 days, there was no significant difference in major adverse cardiac events (MACE), defined as cardiac death, myocardial infarction including periprocedural myocardial infarction, target vessel revascularisation, between the two groups (p=0.585). Independent predictors of MACE on multivariate Cox regression analysis included stent-in-stent (HR: 2.16; 95% CI: 1.11 to 4.20; p=0.023) and true bifurcation lesions (HR: 2.98; 95% CI: 1.45 to 6.14; p=0.001). Conclusions: DEB for bifurcation restenosis may be an acceptable treatment option, especially in cases where repeat stenting has not already been performed for the treatment of a previous restenosis.

Original languageEnglish (US)
Pages (from-to)989-995
Number of pages7
Issue number9
StatePublished - Jan 2016
Externally publishedYes


  • Coronary bifurcation
  • Drug-eluting balloon
  • In-stent restenosis
  • Second-generation drug-eluting stent

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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