@article{35d22090f0f74f95b2afd743e06ee4fe,
title = "Dose-response relationship between late-life physical activity and incident dementia: A pooled analysis of 10 cohort studies of memory in an international consortium",
abstract = "Introduction: Though consistent evidence suggests that physical activity may delay dementia onset, the duration and amount of activity required remains unclear. Methods: We harmonized longitudinal data of 11,988 participants from 10 cohorts in eight countries to examine the dose-response relationship between late-life physical activity and incident dementia among older adults. Results: Using no physical activity as a reference, dementia risk decreased with duration of physical activity up to 3.1 to 6.0 hours/week (hazard ratio [HR] 0.88, 95% confidence interval [CI] 0.67 to 1.15 for 0.1 to 3.0 hours/week; HR 0.68, 95% CI 0.52 to 0.89 for 3.1 to 6.0 hours/week), but plateaued with higher duration. For the amount of physical activity, a similar pattern of dose-response curve was observed, with an inflection point of 9.1 to 18.0 metabolic equivalent value (MET)-hours/week (HR 0.92, 95% CI 0.70 to 1.22 for 0.1 to 9.0 MET-hours/week; HR 0.70, 95% CI 0.53 to 0.93 for 9.1 to 18.0 MET-hours/week). Discussion: This cross-national analysis suggests that performing 3.1 to 6.0 hours of physical activity and expending 9.1 to 18.0/MET-hours of energy per week may reduce dementia risk.",
keywords = "cohort, dementia, dose-response, physical activity, pooled analysis, population-based",
author = "{for Cohort Studies of Memory in an International Consortium (COSMIC)} and Wanqing Wu and Ding Ding and Qianhua Zhao and Zhenxu Xiao and Jianfeng Luo and Mary Ganguli and Hughes, {Tiffany F.} and Erin Jacobsen and Haan, {Mary N.} and {van Dang}, Kristine and Lima-Costa, {Maria Fernanda} and Blay, {Sergio Luis} and {de Castro-Costa}, Erico and Ng, {Tze Pin} and Xinyi Gwee and Qi Gao and Oye Gureje and Akin Ojagbemi and Toyin Bello and Suzana Shahar and Ludin, {Arimi Fitri Mat} and Rivan, {Nurul Fatin Malek} and Nikolaos Scarmeas and Anastasiou, {Costas A.} and Mary Yannakoulia and Henry Brodaty and Crawford, {John D.} and Lipton, {Richard B.} and Derby, {Carol A.} and Katz, {Mindy J.} and Lipnicki, {Darren M.} and Sachdev, {Perminder S.}",
note = "Funding Information: COSMIC management: The head of COSMIC is Perminder S. Sachdev, and the Study Co-ordinator is Darren M. Lipnicki. The Research Scientific Committee leads the scientific agenda of COSMIC and provides ongoing support and governance; it is comprised of member study leaders (in alphabetical order): Kaarin Anstey, Carol Brayne, Henry Brodaty, Liang-Kung Chen, Erico Costa, Michael Crowe, Oscar Del Brutto, Ding Ding, Jacqueline Dominguez, Mary Ganguli, Antonio Guaita, Ma{\"e}lenn Guerchet, Oye Gureje, Jacobijn Gussekloo, Mary Haan, Hugh Hendrie, Ann Hever, Ki-Woong Kim, Seb Koehler, Murali Krishna, Linda Lam, Bagher Larijani, Richard Lipton, Juan Llibre-Rodriguez, Antonio Lobo, Richard Mayeux, Kenichi Meguro, Vincent Mubangizi, Toshiharu Ninimiya, Stella-Maria Paddick, Maria Skaalum Petersen, Ng Tze Pin, Steffi Riedel-Heller, Karen Ritchie, Kenneth Rockwood, Nikolaos Scarmeas, Marcia Scazufca, Suzana Shahar, Xiao Shifu, Kumagai Shuzo, Ingmar Skoog, Yuda Turana. Additional member study leaders: Marie-Laure Ancelin, Mindy Katz, Martin van Boxtel, Iraj Nabipour, Pierre-Marie Preux, Perminder Sachdev, Nicole Schupf, Richard Walker. COSMIC NIH grant investigators: Perminder Sachdev: Scientia Professor of Neuropsychiatry; Co-Director, Centre for Healthy Brain Ageing (CHeBA), UNSW Sydney; Director, Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, Australia. Mary Ganguli: Professor of Psychiatry, Neurology, and Epidemiology, University of Pittsburgh. Ronald Petersen: Professor of Neurology; Director, Mayo Clinic Alzheimer's Disease Research Center and the Mayo Clinic Study of Aging. Richard Lipton: Edwin S. Lowe Professor and Vice Chair of Neurology, Albert Einstein College of Medicine. Karen Ritchie: Professor and Director of the Neuropsychiatry Research Unit of the French National Institute of Research (INSERM U1061). Ki-Woong Kim: Professor of Brain and Cognitive Sciences, Director of National Institute of Dementia of Korea. Louisa Jorm: Director, Centre for Big Data Research in Health and Professor, Faculty of Medicine, UNSW Sydney, Australia. Henry Brodaty: Scientia Professor of Ageing & Mental Health; Co-Director, Centre for Healthy Brain Ageing (CHeBA), UNSW Sydney; Director, Dementia Collaborative Research Centre (DCRC); Senior Consultant, Old Age Psychiatry, Prince of Wales Hospital. We thank the participants and their informants for their time and generosity in contributing to this research. We also acknowledge the research teams for the 10 contributing cohort studies. Funding Information: Ding Ding reports grants from Shanghai Municipal Science and Technology Major Project (2018SHZDZX01) and ZJ LAB, National Natural Science Foundation of China (81773513), Scientific Research Plan Project of Shanghai Science and Technology Committee (17411950701, 17411950106), and National Project of Chronic Disease (2016YFC1306402). All payments were made to the institution. Qianhua Zhao reports grants from the National Chronic Disease Project (2016YFC1306402), Shanghai Science and Technology Municipality (17411950106, 2018SHZDZX03, 17411950701), National Natural Science Foundation of China (82071200, 81773513), Shanghai Hospital Development Center (SHDC2020CR4007), MOE Frontiers Center for Brain Science (JIH2642001/028). All payments were made to the institution. Qianhua Zhao has received honoraria for lectures from Green Valley, Eisai, Lundbeck, Novartis Co. Ltd. Mary Ganguli reports grants from the National Institute on Aging (NIA), National Institutes of Health (NIH), US DHHS (R37 AG023651) to the University of Pittsburgh. She has received consulting fees from the University of Texas Health Sciences Center, San Antonio and support for travel from Mount Sinai Medical Center, Miami Beach and University of Texas Health Sciences Center, San Antonio. Mary Ganguli has participated on the Data Safety Monitoring Board or Advisory Board of the University of Texas Health Sciences Center, San Antonio and Indiana University. Mary N. Haan has received consulting fees from Northeastern Medical School, Chicago, Illinois. She has held a leadership in the School of Medicine, the University of California at San Francisco and payments were made to herself. Tze Pin Nig reports grants from Biomedical Research Council (BMRC/08/1/21/19/567) and the National Medical Research Council (NMRC/1108/2007; NMRC/CIRG/1409/2014). Support to himself as principal investigator. He has received lecture honorarium from the Singapore Institute of Technology. Payments were made to himself. Oye Gureje has participated in the Nigerian Institute of Medical Research Advisory Board. No payments were received. Arimi Fitri Mat Ludin reports grants from Powerlife (M) Sdn Bhd and payments for a public talk from Perbadanan Putrajaya. All payments were made to the institution. Nikolaos Scarmeas reports grants from Alzheimer's Association (IIRG‐09‐133014), ESPA‐EU program Excellence Grant (189 10276/8/9/2011) co‐funded by European Social Fund and Greek National resources, and the Ministry of Health and Social Solidarity (DY2b/oik.51657/14.4.2009). He has received support from EISAI and EPAD. All payments were made to his institution. He has received honorarium for delivering three scientific presentations in Korea from EISAI Korea. He is the Chair of the Data Safety Monitoring Board of an NIH‐funded study in Albert Einstein College of Medicine. Payments were made to himself. Mary Yannakoulia reports institutional grant through the Operational Program “Human Resources Development, Education and Lifelong Learning 2014 to 2020.” She is a member of the National Nutrition Policy Committee. Henry Brodaty reports grants from the National Health and Medical Research Council, New South Wales Health and Commonwealth Department of Health to his institution. He has received consulting fees from Biogen Pharma and Advisory Board fees from Roche Pharma. Payments were made to himself. John D. Crawford is employed at the University of New South Wales as a research officer, and his salary is supported by NIA/NIH (RF1AG057531‐01). The project John D. Crawford involved was titled “COSMIC: an international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethno‐racial groups and geographical settings.” Richard B. Lipton reports grants from NIH, the Food and Drug Administration, the S and L Marx Foundation, the Migraine Research Foundation, and the National Headache Foundation. All payments to the institution. He serves as a consultant, advisory board member, has received honoraria from or research support from Abbvie (Allergan), American Academy of Neurology, American Headache Society, Amgen, Biohaven, Biovision, Boston, Dr. Reddy's (Promius), Electrocore, Eli Lilly, eNeura, Equinox, GlaxoSmithKline, Grifols, Lundbeck (Alder), Merck, Pernix, Pfizer, Teva, Vector, and Vedanta. Carol A. Derby and Mindy J. Katz report grants from NIH (AG03949) to Albert Einstein College of Medicine. Darren M. Lipnicki reports grants from the National Health and Medical Research Council of Australia (1093083) to his institution. He has received support from Alzheimer's Association International Conference Satellite Sydney 2019. Payments were made to himself. Perminder S. Sachdev reports grants from NIA/NIH (USA) to the institution. He has received support from the National Health and Medical Research Council of Australia. He is a member of the Advisory Committee in Biogen Australia. He has held a leadership in the Society Executive Committee of the International Society of Vascular Behavioural and Cognitive Disorders and the Executive Committee of the International Neuropsychiatric Association. Wanqing Wu, Zhenxu Xiao, Jianfeng Luo, Tiffany F. Hughes, Erin Jacobsen, Kristine van Dang, Maria Fernanda Lima‐Costa, Sergio Luis Blay, Erico de Castro‐Costa, Xinyi Gwee, Qi Gao, Akin Ojagbemi, Toyin Bello, Suzana Shahar, Nurul Fatin Malek Rivan, and Costas A. Anastasiou have declared no conflicts of interest. Publisher Copyright: {\textcopyright} 2022 the Alzheimer's Association.",
year = "2023",
month = jan,
doi = "10.1002/alz.12628",
language = "English (US)",
volume = "19",
pages = "107--122",
journal = "Alzheimer's and Dementia",
issn = "1552-5260",
publisher = "Elsevier Inc.",
number = "1",
}
