DNA ploidy of fibrolamellar hepatocellular carcinoma by image analysis

Giulia Orsatti, Pietra D. Greenberg, Donald B. Rolfes, Kamal G. Ishak, Fiorenzo Paronetto

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Twelve cases of fibrolamellar hepatocellular carcinoma (FLC) were evaluated for DNA ploidy by means of image analysis of Feulgenstained tissue sections. All of the tumors showed a nondiploid DNA distribution (six aneuploid and six tetraploid); no diploid pattern was found. The nuclear area of the tumors (53.8 μm2 ± 18.0; mean ± standard deviation) was significantly larger than that of the surrounding noncancerous livers (33.2 ± 4.7; P < .0001). These findings suggest that DNA content in fibrolamellar carcinoma (FLC) is not directly related to the clinical behavior and that other factors may be responsible for the better prognosis of this variant of HCC.

Original languageEnglish (US)
Pages (from-to)936-939
Number of pages4
JournalHuman Pathology
Issue number9
StatePublished - Sep 1994


  • DNA ploidy
  • fibrolamellar carcinoma
  • hepatocellular carcinoma
  • nuclear DNA content

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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