Distinct lymphoblastic and myeloblastic populations in tdt positive acute myeloblastic leukemia: Evidence by double-fluorescence staining

Elisabeth Paietta; Peter Bettelheim; Josef D. Schwarzmeier; Dieter Lutz; Otto Majdic; Walter Knapp

doi:10.1016/0145-2126(83)90021-8

Distinct lymphoblastic and myeloblastic populations in tdt positive acute myeloblastic leukemia: Evidence by double-fluorescence staining

Elisabeth Paietta
, Peter Bettelheim
, Josef D. Schwarzmeier
, Dieter Lutz
, Otto Majdic
, Walter Knapp

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Double-immunofluorescent staining for the enzyme terminal deoxynucleotidyl transferase (TdT) as a marker of primitive lymphoblasts, and for the VIM-D5 antigen as a differentiation antigen of the myeloid system gave direct evidence for distinct lymphoblastic and myeloblastic populations (mixed leukemic cell populations) in seven patients with acute leukemia. The percentage of malignant TdT positive cells contributing to a leukemic cell bulk with unequivocal signs of myeloid origin was between 10 and 80%. A defect at the level of a common progenitor cell giving rise to both the TdT and the VIM-D5 positive blast cell population is discussed.

Original language	English (US)
Pages (from-to)	301-305,307
Journal	Leukemia Research
Volume	7
Issue number	2
DOIs	https://doi.org/10.1016/0145-2126(83)90021-8
State	Published - 1983
Externally published	Yes

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SDG 3 Good Health and Well-being

Keywords

Acute myeloblastic leukemia
double-fluorescence staining
terminal transferase

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

Access to Document

10.1016/0145-2126(83)90021-8

Cite this

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title = "Distinct lymphoblastic and myeloblastic populations in tdt positive acute myeloblastic leukemia: Evidence by double-fluorescence staining",

abstract = "Double-immunofluorescent staining for the enzyme terminal deoxynucleotidyl transferase (TdT) as a marker of primitive lymphoblasts, and for the VIM-D5 antigen as a differentiation antigen of the myeloid system gave direct evidence for distinct lymphoblastic and myeloblastic populations (mixed leukemic cell populations) in seven patients with acute leukemia. The percentage of malignant TdT positive cells contributing to a leukemic cell bulk with unequivocal signs of myeloid origin was between 10 and 80\%. A defect at the level of a common progenitor cell giving rise to both the TdT and the VIM-D5 positive blast cell population is discussed.",

keywords = "Acute myeloblastic leukemia, double-fluorescence staining, terminal transferase",

author = "Elisabeth Paietta and Peter Bettelheim and Schwarzmeier, \{Josef D.\} and Dieter Lutz and Otto Majdic and Walter Knapp",

note = "Funding Information: *Supported by grants of the Fonds zur FOrderung der wissenschaftlichen Forschung in Osterreich (projects Nos. 2746, 4106, 4544), and by the Medizinisch wissenschaftlichen Fonds des Bttrgermeisters der Stadt Wien. Abbreviations: TdT, terminal deoxynucleotidyl transferase; AML, acute myeloblastic leukemia; ALL, acute lymphoblastic leukemia; cALL antigen, common ALL antigen; POX, myeloperoxidase; PAS, periodic acid-Schiff; EST, non-specific esterase using alpha-naphthyl-acetate as substrate; phi, Philadelphia chromosome. Correspondence to: Dr. Elisabeth Paietta, First Medical Department, University of Vienna Medical School, Lazarettgasse 14, A-1090 Vienna, Austria.",

year = "1983",

doi = "10.1016/0145-2126(83)90021-8",

language = "English (US)",

volume = "7",

pages = "301--305,307",

journal = "Leukemia Research",

issn = "0145-2126",

publisher = "Elsevier Ltd",

number = "2",

}

TY - JOUR

T1 - Distinct lymphoblastic and myeloblastic populations in tdt positive acute myeloblastic leukemia

T2 - Evidence by double-fluorescence staining

AU - Paietta, Elisabeth

AU - Bettelheim, Peter

AU - Schwarzmeier, Josef D.

AU - Lutz, Dieter

AU - Majdic, Otto

AU - Knapp, Walter

N1 - Funding Information: *Supported by grants of the Fonds zur FOrderung der wissenschaftlichen Forschung in Osterreich (projects Nos. 2746, 4106, 4544), and by the Medizinisch wissenschaftlichen Fonds des Bttrgermeisters der Stadt Wien. Abbreviations: TdT, terminal deoxynucleotidyl transferase; AML, acute myeloblastic leukemia; ALL, acute lymphoblastic leukemia; cALL antigen, common ALL antigen; POX, myeloperoxidase; PAS, periodic acid-Schiff; EST, non-specific esterase using alpha-naphthyl-acetate as substrate; phi, Philadelphia chromosome. Correspondence to: Dr. Elisabeth Paietta, First Medical Department, University of Vienna Medical School, Lazarettgasse 14, A-1090 Vienna, Austria.

PY - 1983

Y1 - 1983

N2 - Double-immunofluorescent staining for the enzyme terminal deoxynucleotidyl transferase (TdT) as a marker of primitive lymphoblasts, and for the VIM-D5 antigen as a differentiation antigen of the myeloid system gave direct evidence for distinct lymphoblastic and myeloblastic populations (mixed leukemic cell populations) in seven patients with acute leukemia. The percentage of malignant TdT positive cells contributing to a leukemic cell bulk with unequivocal signs of myeloid origin was between 10 and 80%. A defect at the level of a common progenitor cell giving rise to both the TdT and the VIM-D5 positive blast cell population is discussed.

AB - Double-immunofluorescent staining for the enzyme terminal deoxynucleotidyl transferase (TdT) as a marker of primitive lymphoblasts, and for the VIM-D5 antigen as a differentiation antigen of the myeloid system gave direct evidence for distinct lymphoblastic and myeloblastic populations (mixed leukemic cell populations) in seven patients with acute leukemia. The percentage of malignant TdT positive cells contributing to a leukemic cell bulk with unequivocal signs of myeloid origin was between 10 and 80%. A defect at the level of a common progenitor cell giving rise to both the TdT and the VIM-D5 positive blast cell population is discussed.

KW - Acute myeloblastic leukemia

KW - double-fluorescence staining

KW - terminal transferase

UR - https://www.scopus.com/pages/publications/0020639886

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U2 - 10.1016/0145-2126(83)90021-8

DO - 10.1016/0145-2126(83)90021-8

M3 - Article

C2 - 6343731

AN - SCOPUS:0020639886

SN - 0145-2126

VL - 7

SP - 301-305,307

JO - Leukemia Research

JF - Leukemia Research

IS - 2

ER -

Distinct lymphoblastic and myeloblastic populations in tdt positive acute myeloblastic leukemia: Evidence by double-fluorescence staining

Abstract

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Keywords

ASJC Scopus subject areas

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