@article{4029fbf2e8bf4f258845fba8ac82e1db,
title = "Distinct lymphoblastic and myeloblastic populations in tdt positive acute myeloblastic leukemia: Evidence by double-fluorescence staining",
abstract = "Double-immunofluorescent staining for the enzyme terminal deoxynucleotidyl transferase (TdT) as a marker of primitive lymphoblasts, and for the VIM-D5 antigen as a differentiation antigen of the myeloid system gave direct evidence for distinct lymphoblastic and myeloblastic populations (mixed leukemic cell populations) in seven patients with acute leukemia. The percentage of malignant TdT positive cells contributing to a leukemic cell bulk with unequivocal signs of myeloid origin was between 10 and 80%. A defect at the level of a common progenitor cell giving rise to both the TdT and the VIM-D5 positive blast cell population is discussed.",
keywords = "Acute myeloblastic leukemia, double-fluorescence staining, terminal transferase",
author = "Elisabeth Paietta and Peter Bettelheim and Schwarzmeier, {Josef D.} and Dieter Lutz and Otto Majdic and Walter Knapp",
note = "Funding Information: *Supported by grants of the Fonds zur FOrderung der wissenschaftlichen Forschung in Osterreich (projects Nos. 2746, 4106, 4544), and by the Medizinisch wissenschaftlichen Fonds des Bttrgermeisters der Stadt Wien. Abbreviations: TdT, terminal deoxynucleotidyl transferase; AML, acute myeloblastic leukemia; ALL, acute lymphoblastic leukemia; cALL antigen, common ALL antigen; POX, myeloperoxidase; PAS, periodic acid-Schiff; EST, non-specific esterase using alpha-naphthyl-acetate as substrate; phi, Philadelphia chromosome. Correspondence to: Dr. Elisabeth Paietta, First Medical Department, University of Vienna Medical School, Lazarettgasse 14, A-1090 Vienna, Austria.",
year = "1983",
doi = "10.1016/0145-2126(83)90021-8",
language = "English (US)",
volume = "7",
pages = "301--305,307",
journal = "Leukemia Research",
issn = "0145-2126",
publisher = "Elsevier Limited",
number = "2",
}
