Distant metastases from head and neck squamous cell carcinoma. Part I. Basic aspects

Robert P. Takes, Alessandra Rinaldo, Carl E. Silver, Missak Haigentz, Julia A. Woolgar, Asterios Triantafyllou, Vanni Mondin, Daniela Paccagnella, Remco De Bree, Ashok R. Shaha, Dana M. Hartl, Alfio Ferlito

Research output: Contribution to journalReview articlepeer-review

139 Scopus citations


The incidence of distant metastasis in head and neck squamous cell carcinoma (HNSCC) is relatively low but remains a major determinant of prognosis and therefore an important factor in clinical decision making. The most frequently involved sites for distant metastasis are the lung (approximately 70% of cases), followed by bone and liver. There are often conflicting reports on which parameters are risk factors for distant metastasis, but the most important predictive factors appear to be the site of the primary tumor (hypopharynx in particular), advanced T- and N-classification, histological grade and the ability to achieve locoregional disease control. Metastasis results from a selection of tumor cells that have acquired the properties to withstand multiple and often unfavorable circumstances and settle in distant organs. Most of these processes involve interaction between tumor cells, their microenvironment and host factors. Increasing knowledge of the biology of distant metastasis may result in the development of diagnostic and therapeutic strategies targeted to this usually terminal stage for patients with HNSCC.

Original languageEnglish (US)
Pages (from-to)775-779
Number of pages5
JournalOral Oncology
Issue number9
StatePublished - Sep 2012


  • Cancer invasion
  • Distant metastases
  • Head and neck squamous cell carcinoma
  • Metastasis
  • Sites of distant metastases

ASJC Scopus subject areas

  • Oral Surgery
  • Oncology
  • Cancer Research


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