Dissociation between thyroxine metabolism and hormonal action in phenobarbital-treated rats

Jack H. Oppenheimer; Harvey C. Shapiro; Harold L. Schwartz; Martin I. Surks

doi:10.1210/endo-88-1-115

Dissociation between thyroxine metabolism and hormonal action in phenobarbital-treated rats

Jack H. Oppenheimer, Harvey C. Shapiro, Harold L. Schwartz, Martin I. Surks

Medicine

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17 Scopus citations

Abstract

Phenobarbital injection reduces the biologic effectiveness of thyroxine in thyroidectomized rats maintained on a constant daily dose of hormone. This was inferred from measurements of total body oxygen consumption and the activity of the mitochondrial enzyme alpha-glycerophosphate dehydrogenase in liver, heart and kidney. No changes in these parameters were observed when intact rats were given phenobarbital alone. Thus, the increased hepatocellular binding and deiodination of T₄ stimulated by phenobarbital is not related to the biologic action of the hormone. On the contrary, phenobarbital administration reduces the biologic effectiveness of administered thyroxine by diverting hormone from extrahepatic and from specific intrahepatic sites of action.

Original language	English (US)
Pages (from-to)	115-119
Number of pages	5
Journal	Endocrinology
Volume	88
Issue number	1
DOIs	https://doi.org/10.1210/endo-88-1-115
State	Published - Jan 1971

ASJC Scopus subject areas

Endocrinology

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abstract = "Phenobarbital injection reduces the biologic effectiveness of thyroxine in thyroidectomized rats maintained on a constant daily dose of hormone. This was inferred from measurements of total body oxygen consumption and the activity of the mitochondrial enzyme alpha-glycerophosphate dehydrogenase in liver, heart and kidney. No changes in these parameters were observed when intact rats were given phenobarbital alone. Thus, the increased hepatocellular binding and deiodination of T4 stimulated by phenobarbital is not related to the biologic action of the hormone. On the contrary, phenobarbital administration reduces the biologic effectiveness of administered thyroxine by diverting hormone from extrahepatic and from specific intrahepatic sites of action.",

author = "Oppenheimer, {Jack H.} and Shapiro, {Harvey C.} and Schwartz, {Harold L.} and Surks, {Martin I.}",

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AU - Surks, Martin I.

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N2 - Phenobarbital injection reduces the biologic effectiveness of thyroxine in thyroidectomized rats maintained on a constant daily dose of hormone. This was inferred from measurements of total body oxygen consumption and the activity of the mitochondrial enzyme alpha-glycerophosphate dehydrogenase in liver, heart and kidney. No changes in these parameters were observed when intact rats were given phenobarbital alone. Thus, the increased hepatocellular binding and deiodination of T4 stimulated by phenobarbital is not related to the biologic action of the hormone. On the contrary, phenobarbital administration reduces the biologic effectiveness of administered thyroxine by diverting hormone from extrahepatic and from specific intrahepatic sites of action.

AB - Phenobarbital injection reduces the biologic effectiveness of thyroxine in thyroidectomized rats maintained on a constant daily dose of hormone. This was inferred from measurements of total body oxygen consumption and the activity of the mitochondrial enzyme alpha-glycerophosphate dehydrogenase in liver, heart and kidney. No changes in these parameters were observed when intact rats were given phenobarbital alone. Thus, the increased hepatocellular binding and deiodination of T4 stimulated by phenobarbital is not related to the biologic action of the hormone. On the contrary, phenobarbital administration reduces the biologic effectiveness of administered thyroxine by diverting hormone from extrahepatic and from specific intrahepatic sites of action.

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Dissociation between thyroxine metabolism and hormonal action in phenobarbital-treated rats

Abstract

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