Disseminated langerhans cell histiocytosis presenting as cholestatic jaundice

Rohit Kapoor, Anthony M. Loizides, Soumya Sachdeva, Premila Paul

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Langerhans cell histiocytosis (LCH) is a disorder associated with proliferation of Langerhans cells in various organs. LCH secondary to multisystem involvement can present in a variety of ways. Because of its infiltrative nature, LCH can involve the skin, lymph nodes, the lung or the liver. Jaundice in LCH is a manifestation of liver disease; biliary dilatation secondary to lithiasis or may be due to coexistent Niemann-Pick disease. However, a case of cholestasis has been very rarely described. Cholestasis may result from lymph nodes obstructing the porta hepatis. In this report, we describe a case of type II histiocytosis X with obstructive cholestasis and pulmonary involvement in the form of cysts without significant lymphadenopathy at the porta.

Original languageEnglish (US)
Pages (from-to)SD03-SD05
JournalJournal of Clinical and Diagnostic Research
Issue number2
StatePublished - 2015


  • Cholestasis
  • Lymphadenopathy
  • Porta hepatis

ASJC Scopus subject areas

  • Clinical Biochemistry


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