Disorders of bilirubin metabolism

Namita Roy Chowdhury, Yanfeng Li, Jayanta Roy Chowdhury

Research output: Chapter in Book/Report/Conference proceedingChapter


This chapter provides a brief summary of bilirubin metabolism and its inherited disorders, with emphasis on some significant developments. Serum bilirubin levels were found to be inversely related to the risk of obesity and metabolic syndrome and ischemic coronary artery disease in middle-aged men. Unconjugated bilirubin binds more tightly to albumin than conjugated bilirubin. Neonatal hyperbilirubinemia results from a combination of increased bilirubin production and lower hepatic bilirubin excretory capacity. Although clinicians are generally concerned with serum bilirubin levels as an indicator of liver function and disease, and the toxicity of bilirubin, within a near-physiological range of plasma concentrations, the antioxidative action of bilirubin may provide beneficial effects. Liver biopsy shows noninflammatory intrahepatic cholestasis without fibrosis, notwithstanding the number and severity of the attacks. The progressive familial intrahepatic cholestasis syndro.

Original languageEnglish (US)
Title of host publicationThe Liver
Subtitle of host publicationBiology and Pathobiology
Number of pages16
ISBN (Electronic)9781119436812
ISBN (Print)9781119436829
StatePublished - Jan 24 2020
Externally publishedYes


  • Bilirubin metabolism disorders
  • Conjugated hyperbilirubinemia
  • Hepatic metabolism
  • Inherited cholestasis syndromes
  • Unconjugated hyperbilirubinemia

ASJC Scopus subject areas

  • Medicine(all)


Dive into the research topics of 'Disorders of bilirubin metabolism'. Together they form a unique fingerprint.

Cite this