Disaggregation of particles with biospecific interactions in shear flow

Andrei A. Potanin; Vladislav V. Verkhusha; Vladimir M. Muller

doi:10.1006/jcis.1996.4745

Disaggregation of particles with biospecific interactions in shear flow

Andrei A. Potanin, Vladislav V. Verkhusha, Vladimir M. Muller

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The disaggregation of biospecifically interacting particles in shear flow is studied on the basis of kinetic modeling of formation and breakup of ligand-receptor bonds. The reaction rate theory is employed to improve earlier estimations of the critical force required to separate the surfaces. A chain of particles connected through ligand-receptor bonds responds to an external load as a contorted elastic rod. The breakup of the many-particle aggregate is attributed to the rupture of the backbone rod-like chain of particles. The theoretical model is found to be in good agreement with our experimental data on disaggregation of particles of latex immunoconjugates and blood platelets in shear flow.

Original language	English (US)
Pages (from-to)	251-256
Number of pages	6
Journal	Journal of Colloid And Interface Science
Volume	188
Issue number	2
DOIs	https://doi.org/10.1006/jcis.1996.4745
State	Published - Apr 15 1997
Externally published	Yes

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Biomaterials
Surfaces, Coatings and Films
Colloid and Surface Chemistry

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10.1006/jcis.1996.4745

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abstract = "The disaggregation of biospecifically interacting particles in shear flow is studied on the basis of kinetic modeling of formation and breakup of ligand-receptor bonds. The reaction rate theory is employed to improve earlier estimations of the critical force required to separate the surfaces. A chain of particles connected through ligand-receptor bonds responds to an external load as a contorted elastic rod. The breakup of the many-particle aggregate is attributed to the rupture of the backbone rod-like chain of particles. The theoretical model is found to be in good agreement with our experimental data on disaggregation of particles of latex immunoconjugates and blood platelets in shear flow.",

author = "Potanin, {Andrei A.} and Verkhusha, {Vladislav V.} and Muller, {Vladimir M.}",

note = "Funding Information: We gratefully acknowledge the support of the International Science Foundation (Soros Foundation), Project NCY000.",

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T1 - Disaggregation of particles with biospecific interactions in shear flow

AU - Potanin, Andrei A.

AU - Verkhusha, Vladislav V.

AU - Muller, Vladimir M.

N1 - Funding Information: We gratefully acknowledge the support of the International Science Foundation (Soros Foundation), Project NCY000.

PY - 1997/4/15

Y1 - 1997/4/15

N2 - The disaggregation of biospecifically interacting particles in shear flow is studied on the basis of kinetic modeling of formation and breakup of ligand-receptor bonds. The reaction rate theory is employed to improve earlier estimations of the critical force required to separate the surfaces. A chain of particles connected through ligand-receptor bonds responds to an external load as a contorted elastic rod. The breakup of the many-particle aggregate is attributed to the rupture of the backbone rod-like chain of particles. The theoretical model is found to be in good agreement with our experimental data on disaggregation of particles of latex immunoconjugates and blood platelets in shear flow.

AB - The disaggregation of biospecifically interacting particles in shear flow is studied on the basis of kinetic modeling of formation and breakup of ligand-receptor bonds. The reaction rate theory is employed to improve earlier estimations of the critical force required to separate the surfaces. A chain of particles connected through ligand-receptor bonds responds to an external load as a contorted elastic rod. The breakup of the many-particle aggregate is attributed to the rupture of the backbone rod-like chain of particles. The theoretical model is found to be in good agreement with our experimental data on disaggregation of particles of latex immunoconjugates and blood platelets in shear flow.

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Disaggregation of particles with biospecific interactions in shear flow

Abstract

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