Dirty dealing: Hepatic vagal afferents reshuffle fat distribution

Gary J. Schwartz

doi:10.1016/j.cmet.2006.07.005

Dirty dealing: Hepatic vagal afferents reshuffle fat distribution

Gary J. Schwartz

Medicine

Research output: Contribution to journal › Short survey › peer-review

1 Scopus citations

Abstract

To evaluate the role of hepatic peroxisome-proliferator-activated receptor (PPAR) γ 2 in the control of energy balance, Uno and colleagues examined the metabolic effects of overexpression of PPAR γ 2 selectively in mouse and rat liver. Mice demonstrated a surprising degree of hepatic steatosis accompanied by significant reductions in peripheral adiposity. This crosstalk between liver and adipose tissue appears to be mediated by both the sensory component of the hepatic vagus nerve and sympathetic efferents. These data suggest a novel hepatic-adipose neuraxis that regulates the distribution of stored fat.

Original language	English (US)
Pages (from-to)	103-105
Number of pages	3
Journal	Cell metabolism
Volume	4
Issue number	2
DOIs	https://doi.org/10.1016/j.cmet.2006.07.005
State	Published - Aug 2006

ASJC Scopus subject areas

Physiology
Molecular Biology
Cell Biology

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10.1016/j.cmet.2006.07.005

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title = "Dirty dealing: Hepatic vagal afferents reshuffle fat distribution",

abstract = "To evaluate the role of hepatic peroxisome-proliferator-activated receptor (PPAR) γ 2 in the control of energy balance, Uno and colleagues examined the metabolic effects of overexpression of PPAR γ 2 selectively in mouse and rat liver. Mice demonstrated a surprising degree of hepatic steatosis accompanied by significant reductions in peripheral adiposity. This crosstalk between liver and adipose tissue appears to be mediated by both the sensory component of the hepatic vagus nerve and sympathetic efferents. These data suggest a novel hepatic-adipose neuraxis that regulates the distribution of stored fat.",

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AB - To evaluate the role of hepatic peroxisome-proliferator-activated receptor (PPAR) γ 2 in the control of energy balance, Uno and colleagues examined the metabolic effects of overexpression of PPAR γ 2 selectively in mouse and rat liver. Mice demonstrated a surprising degree of hepatic steatosis accompanied by significant reductions in peripheral adiposity. This crosstalk between liver and adipose tissue appears to be mediated by both the sensory component of the hepatic vagus nerve and sympathetic efferents. These data suggest a novel hepatic-adipose neuraxis that regulates the distribution of stored fat.

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Dirty dealing: Hepatic vagal afferents reshuffle fat distribution

Abstract

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