Dirty dealing: Hepatic vagal afferents reshuffle fat distribution

Research output: Contribution to journalShort surveypeer-review

1 Scopus citations


To evaluate the role of hepatic peroxisome-proliferator-activated receptor (PPAR) γ 2 in the control of energy balance, Uno and colleagues examined the metabolic effects of overexpression of PPAR γ 2 selectively in mouse and rat liver. Mice demonstrated a surprising degree of hepatic steatosis accompanied by significant reductions in peripheral adiposity. This crosstalk between liver and adipose tissue appears to be mediated by both the sensory component of the hepatic vagus nerve and sympathetic efferents. These data suggest a novel hepatic-adipose neuraxis that regulates the distribution of stored fat.

Original languageEnglish (US)
Pages (from-to)103-105
Number of pages3
JournalCell metabolism
Issue number2
StatePublished - Aug 2006

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology


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